Premorbid adjustment in schizophrenia and schizoaffective disorder
Premorbid adjustment in schizophrenia and schizoaffective disorder
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DOI：
10.1016/j.psychres.2007.11.004
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发表时间：
2009-02-28
影响因子：
11.3
通讯作者：
Fresan, Ana
中科院分区：
文献类型：
--
作者：
Saracco-Alvarez, Ricardo;Rodriguez-Verdugo, Soledad;Fresan, Ana
有证据表明，病前调整可以区分精神分裂症和分裂情感障碍。在评估前6个月，我们招募了41名精神分裂症患者和24名无药物滥用的分裂情感障碍患者。诊断基于DSM-IV的结构化临床访谈。用阳性和阴性症状量表评定精神病性症状，用卡尔加里抑郁量表评定抑郁症状，用全球功能评定量表评定全球心理社会功能。用病前调整量表评价病前适应情况。精神分裂症患者病前适应能力较分裂情感性障碍患者差。精神分裂症患者在“同伴关系”和“学习成绩”方面存在缺陷。在两组患者中，病前调整生命周期和症状严重程度之间存在显著的相关性。不同组之间的差异可能与精神分裂症组发病较早有关。病前调整可能是区分分裂情感性障碍和精神分裂症的有用的临床特征。(C)2007爱思唯尔爱尔兰有限公司。保留所有权利。
There is evidence that premorbid adjustment can differentiate schizophrenia from schizoaffective disorder. We recruited 41 patients with schizophrenia and 24 patients with schizoaffective disorder without substance abuse 6 months before the assessment. Diagnoses were based on the Structured Clinical Interview for DSM-IV. Psychotic symptoms were rated with the Positive and Negative Syndrome Scale, the Calgary Depression Scale was used to assess depressive symptoms, and the Global Assessment of Functioning Scale was used to rate global psychosocial functioning. Premorbid adjustment was evaluated with the Premorbid Adjustment Scale. Patients with schizophrenia showed worse premorbid adjustment compared with the patients with schizoaffective disorder. The areas of "peer relationships" and "scholastic performance" showed deficits in schizophrenia. Significant associations were found between premorbid adjustment life periods and symptom severity in both groups. Differences found between groups may be related to an earlier illness onset in the schizophrenic group. Premorbid adjustment may be a useful clinical feature to differentiate schizoaffective disorder from schizophrenia. (C) 2007 Elsevier Ireland Ltd. All rights reserved.