Nuclear factor-κB (NF-κB) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy
Nuclear factor-κB (NF-κB) and cyclooxygenase-2 (COX-2) expression in the oral mucosa following cancer chemotherapy
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DOI：
10.1016/j.oraloncology.2006.04.011
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发表时间：
2007-04-01
期刊：
影响因子：
4.8
通讯作者：
Keefe, Dorothy M. K.
中科院分区：
文献类型：
--
作者：
Logan, Richard M.;Gibson, Rachel J.;Keefe, Dorothy M. K.
口腔粘膜炎是癌症治疗的一种严重和使人衰弱的副作用。对粘膜炎病理生物学的更深入理解最近导致了针对特定患者人群的靶向治疗的出现;然而，粘膜炎的治疗对大多数患者来说仍然是姑息性的。核因子-κ B（NF-κ B）和环氧合酶2（考克斯-2）被认为在粘膜炎的发生发展中起重要作用。在这项研究中，20例接受细胞毒化疗的患者在细胞毒化疗前后进行了口腔粘膜活检。使用常规免疫组织化学对样本进行NF-κ B和考克斯-2染色。该初步研究的结果表明，细胞毒性化疗后NF-κ B和COX-2的口腔粘膜染色显著增加，并进一步支持NF-κ B和考克斯-2在粘膜炎发病机制中的作用。(c)2006爱思唯尔有限公司保留所有权利。
Oral mucositis is a serious and debilitating side effect of cancer treatment. Greater understanding of the pathobiology of mucositis has recently led to the advent of targeted treatments for specific patient populations; however the treatment for mucositis remains palliative for most patients. Nuclear factor-kappaB (NF-kappa B) and cyclooxygenase 2 (COX-2) are thought to play important roles in the development of mucositis. In this study, 20 patients undergoing cytotoxic chemotherapy had oral mucosal biopsies taken prior to and following administration of cytotoxic chemotherapy. The samples were stained for NF-kappa B and COX-2 using routine immunohistochemistry. The results from this preliminary study demonstrated statistically significant increased oral mucosal staining for NF-kappa B and COX-2 following cytotoxic chemotherapy and provide further support for the role of NF-kappa B and COX-2 in the pathogenesis of mucositis. (c) 2006 Elsevier Ltd. All rights reserved.