Stimulus complexity enhances auditory discrimination in patients with extremely severe brain injuries
Stimulus complexity enhances auditory discrimination in patients with extremely severe brain injuries
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DOI：
10.1016/j.neulet.2003.08.045
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发表时间：
2003-12-04
影响因子：
2.5
通讯作者：
Birbaumer, N
中科院分区：
文献类型：
--
作者：
Kotchoubey, B;Lang, S;Birbaumer, N
关于人类听觉皮层对频谱丰富的声音的处理在多大程度上与对单一频率的处理有关，存在争议。失配负性（MMN）是听觉事件相关电位的一个组成部分，是听觉皮层功能的一个信息指标，对神经系统患者尤为重要。本研究记录了79例极严重弥漫性脑损伤患者的MMN，其中大多数患者处于持续性植物状态或最低意识状态。正弦波（“纯”）和复杂的音乐音调都被使用。不同的统计方法趋于一致，音乐音调比简单的正弦音调更频繁地引发MMN，幅度更大。这意味着在临床人群中使用简单的刺激可能会导致对患者听觉系统功能状态的严重低估。这些发现也与行为和生理数据一致，表明听觉皮层独立处理复杂的声音。(C) 2003年由爱思唯尔爱尔兰有限公司出版
There is controversy as to what extent the processing of spectrally rich sounds in the human auditory cortex is related to the processing of singular frequencies. An informative index of the function of the auditory cortex, particularly important in neurological patients, is the mismatch negativity (MMN), a component of auditory event-related potentials. In the present study the MMN was recorded in 79 patients with extremely severe diffuse brain injuries, most of them in persistent vegetative state or minimal consciousness state. Both sinusoidat ('pure') and complex musical tones were used. Different statistical approaches converged in that musical tones elicited an MMN significantly more frequently, and of a larger amplitude, than simple sine tones. This implies that using simple stimuli in clinical populations may lead to a severe underestimation of the functional state of a patient's auditory system. The findings are also in line with behavioral and physiological data indicating independent processing of complex sounds in the auditory cortex. (C) 2003 Published by Elsevier Ireland Ltd.