Relationship between hematopoietic parameters and behavioral measures in lead-exposed rats.
Relationship between hematopoietic parameters and behavioral measures in lead-exposed rats.
复制标题
铅暴露大鼠造血参数与行为测量之间的关系。
DOI：
10.1016/0041-008x(84)90094-2
复制
发表时间：
1984
影响因子：
3.8
通讯作者：
Sekeres,R
中科院分区：
文献类型：
--
作者：
Hastings,L;Zenick,H;Succop,P;Sun,TJ;Sekeres,R
本文研究了低水平铅暴露对发育期大鼠学习成绩的影响，并与个体造血指标进行了相关分析。幼犬通过母畜乳汁接受暴露;母畜在哺乳期暴露于0-，545-或1090-ppm铅。在第30天的年龄，一半的高铅组被放置在蒸馏水，其余组继续相同的暴露方案，他们的母兽。在第20、30和90天，通过心脏穿刺获得所有大鼠的血样。每个样本进行了分析铅浓度，游离红细胞原卟啉（FEP），红细胞压积，血红蛋白。从第90天开始，对所有大鼠进行了一系列任务测试，旨在研究以下问题：（1）铅暴露在多大程度上干扰了逆转学习;（2）任务要求的改变是否会对新任务的获得产生不利影响;（3）任务难度在多大程度上有助于铅诱导的缺陷;以及（4）铅暴露是否会影响短期或长期记忆信息的能力。实际的测试范式包括空间辨别与反转，视觉辨别与反转，视觉辨别任务与延迟。在任何一项任务上，都没有观察到任何组之间的显著差异。个体学习成绩与个体造血功能指标的相关性也没有达到显著性。这些发现表明，在低暴露水平下，铅对这些任务测量的学习和记忆功能几乎没有明显的影响。
The effects of low level lead (Pb) exposure on learning tasks in developing rats were investigated and the results correlated with individual hematopoietic indices. Pups received exposure via the dams milk; dams were exposed to either 0-, 545-, or 1090-ppm Pb during the lactation period. At Day 30 of age, half of the high Pb group was placed on distilled water; the remaining groups continued on the same exposure regimens as their dams. On Days 20, 30, and 90, blood samples for all rats were obtained via cardiac puncture. Each sample was analyzed for Pb concentration, free erythrocyte protoporphyrin (FEPs), hematocrit, and hemoglobin. Beginning at Day 90, all rats were tested on a battery of tasks designed to investigate the following questions: (1) to what degree lead exposure interferes with reversal learning; (2) whether changing of task requirements adversely affects acquisition of a new task; (3) to what extent task difficulty contributes to lead-induced deficits; and (4) whether lead exposure affects the capacity to retain information over short or long periods of time. The actual testing paradigms included spatial discrimination with reversal, visual discrimination with reversal, and visual discrimination task with delay. No significant differences were observed among any of the groups on any of the tasks. Correlation of individual learning scores with individual measures of hematopoietic function also failed to reach significance. These findings indicate that at low exposure levels, lead has little appreciable effect on learning and memory function as measured by these tasks.