Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes
Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes
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DOI：
10.1016/j.bbrc.2004.02.031
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发表时间：
2004-03-26
影响因子：
3.1
通讯作者：
Osawa, T
中科院分区：
文献类型：
--
作者：
Tsuda, T;Ueno, Y;Osawa, T
脂肪细胞功能障碍与肥胖和胰岛素抵抗的发展密切相关。脂肪细胞因子分泌或脂肪细胞特异性基因表达的调控是预防肥胖和改善胰岛素敏感性的重要靶点之一。在这项研究中，我们证明了花青素（花青素或花青素3-葡萄糖苷）在分离的大鼠脂肪细胞中具有独特的药理学功能。花青素处理的脂肪细胞增强脂肪细胞因子（脂联素和瘦素）的分泌和上调脂肪细胞特异性基因的表达，而不激活的PPARgamma在分离的大鼠脂肪细胞。脂联素的基因表达也上调白色脂肪组织中喂食花青素补充饮食的小鼠。作为可能的机制之一，AMP-活化的蛋白激酶活化与这些变化有关，然而，AMP：ATP比显着降低了花青素的管理。这些数据表明，花青素具有独特的治疗优势，对预防肥胖和糖尿病也有重要意义。(C)2004年爱思唯尔公司All rights reserved.
Adipocyte dysfunction is strongly associated with the development of obesity and insulin resistance. It is accepted that the regulation of adipocytokine secretion or the adipocyte-specific gene expression is one of the most important targets for the prevention of obesity and amelioration of insulin sensitivity. In this study, we demonstrated that anthocyanins (cyanidin or cyanidin 3-glucoside) have the potency of a unique pharmacological function in isolated rat adipocytes. Treated adipocytes with anthocyanins enhanced adipocytokine (adiponectin and leptin) secretion and up-regulated the adipocyte specific gene expression without activation of PPARgamma in isolated rat adipocytes. The gene expression of adiponectin was also up-regulated in white adipose tissue in mice fed an anthocyanin supplemented diet. As one of the possible mechanisms, AMP-activated protein kinase activation would be associated with these changes, nevertheless, the AMP:ATP ratio was significantly decreased by administration of the anthocyanins. These data suggest that anthocyanins have a potency of unique therapeutic advantage and also have important implications for preventing obesity and diabetes. (C) 2004 Elsevier Inc. All rights reserved.