Plasticity-related serine proteases in the brain (review).
Plasticity-related serine proteases in the brain (review).
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大脑中与可塑性相关的丝氨酸蛋白酶（综述）。
DOI：
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发表时间：
1999
影响因子：
5.4
通讯作者：
Sadao Shiosaka
中科院分区：
文献类型：
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作者：
S. Yoshida;Sadao Shiosaka
丝氨酸蛋白酶在体内发挥多种功能；食物消化，其他蛋白质的调节和细胞外基质的修饰。越来越多的证据表明丝氨酸蛋白酶在神经系统中的重要性。已有研究表明，凝血酶、纤溶酶原激活剂和神经蛋白酶这三种丝氨酸蛋白酶在神经可塑性中具有功能作用。大多数凝血酶的作用被认为是由其特异性受体介导的。凝血酶逆转血清缺失的神经母细胞瘤细胞的神经突生长，并诱导对神经元和胶质细胞的保护和凋亡作用，这取决于浓度和时间。组织型和尿激酶型纤溶酶原激活剂（tPA和uPA）在大脑中广泛分布。tPA和uPA在发展过程中发挥着多种功能。这些蛋白酶也在长期增强和点燃形成中起作用。此外，tPA对兴奋性毒性神经元细胞死亡至关重要。神经蛋白酶是一种在大脑边缘系统中表达的丝氨酸蛋白酶。点燃诱导的neuropsin mRNA和蛋白表达及抗neuropsin抗体改善点燃癫痫。本文综述了这些蛋白酶在神经可塑性中的可能作用。
Serine proteases exert a variety of functions in the body; food digestion, regulation of other proteins and modification of extracellular matrix. Cumulative evidence has shown the importance of serine proteases in the nervous system as well. It has been shown that three serine proteases, thrombin, plasminogen activators and neuropsin, have functional roles in neural plasticity. Most of the actions of thrombin are thought to be mediated by its specific receptors. Thrombin reverses neurite outgrowth of serum-deprived neuroblastoma cells, and induces protective and apoptotic effects on neurons and glial cells depending on concentration and time. Tissue-type and urokinase-type plasminogen activators (tPA and uPA) distribute broadly in the brain. tPA and uPA exert a variety of functions during development. These proteases also function in long-term potentiation and kindling formation. Furthermore, tPA is essential to excitotoxic neuronal cell death. Neuropsin is a serine protease expressed in the limbic system of the brain. Kindling induced neuropsin mRNA and protein expression and anti-neuropsin antibody ameliorates kindling epilepsy. The possible roles of these proteases in neural plasticity are reviewed here.