Strength in Parkinson's disease: Relationship to rate of force generation and clinical status
Strength in Parkinson's disease: Relationship to rate of force generation and clinical status
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DOI：
10.1002/ana.410390112
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发表时间：
1996-01-01
影响因子：
11.2
通讯作者：
Rothwell, JC
中科院分区：
文献类型：
--
作者：
Corcos, DM;Chen, CM;Rothwell, JC
对9例帕金森病患者进行抗帕金森药物治疗和停用抗帕金森药物治疗，测量其最大肘关节屈肌和伸肌力量。此外，在次最大收缩中测量了力的产生速率、主动返回力到静止水平的速率以及力“松弛”的被动释放。强度和收缩时间的测量与帕金森病统一评定量表测量的临床状态变化相关。当患者停药时，他们在伸展方面的力量减少明显大于屈曲。屈曲强度的降低没有达到统计学意义。伸肌无力主要是由于伸肌的强直性激活减少，而不是肌肉的协同激活。肌肉松弛时间明显长于力产生时间和主动力返回时间。放松时间的增加和伸肌强度的降低都与临床状态的变化相关。最后，伸肌扭矩的变化与主动回力的时间相关，这表明在一些帕金森病患者中，伸肌强度的降低与产生快速收缩的能力降低有关。这些结果表明，帕金森病中肌肉无力的分布不对称，肌肉力量和肌肉松弛的选择测量与临床状态的变化相关。
Maximum elbow flexor and extensor muscle strength was measured in 9 patients with Parkinson's disease on and off antiparkinsonian medication. In addition, the rate of force generation, the rate of actively returning force to resting levels, and passive release of force ''relaxation'' were measured in submaximal contractions. The measures of strength and contraction time were correlated with changes in clinical status as measured by the Unified Parkinson's Disease Rating Scale. When patients were off medication, their reduction in strength was significantly greater in extension than flexion. The reduction in flexion strength did not reach statistical significance. The extensor weakness was primarily due to decreased tonic activation of the extensor muscles and not to muscle coactivation. Muscle relaxation time was much more prolonged than was force generation time or active force return time. The increase in relaxation time and the decrease in extensor strength both correlated with changes in clinical status. Finally, changes in extensor torque correlated with the time to actively return force, suggesting that reduced strength is related to a reduced ability to generate rapid contractions in some patients with Parkinson's disease. These results suggest that there is an asymmetric distribution of muscle weakness in Parkinson's disease and that selected measures of muscle strength and muscle relaxation correlate with changes in clinical status.