Human immunodeficiency virus type 1 (HIV-1)-specific CD8+ TEMRA cells in early infection are linked to control of HIV-1 viremia and predict the subsequent viral load set point
Human immunodeficiency virus type 1 (HIV-1)-specific CD8+ TEMRA cells in early infection are linked to control of HIV-1 viremia and predict the subsequent viral load set point
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DOI：
10.1128/jvi.00045-07
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发表时间：
2007-06-01
影响因子：
5.4
通讯作者：
Michaelsson, Jakob
中科院分区：
文献类型：
--
作者：
Northfield, John W.;Loo, Christopher P.;Michaelsson, Jakob
CD 8（+）T细胞被认为在控制人类免疫缺陷病毒1型（HIV-1）感染中起重要作用。然而，尽管进行了大量的努力，仍然不可能将CD 8（+）T细胞反应的总体幅度与HIV-1的控制一致地联系起来。在这里，我们研究了不同的CD 8（+）记忆T细胞亚群在早期感染中对HIV-1的应答与未来HIV-1病毒血症控制的关系。我们的研究结果表明，HIV-1特异性CD 8（+）CCR 7（-）CD 45 RA（+）效应记忆T细胞（T-EMRA细胞）的比例和绝对数量均与未来较低的病毒载量设定点相关。相反，HIV-1特异性CD 8（+）CCR 7（-）CD 45 RA（-）效应记忆T细胞（T-EM）的绝对数量较大与病毒载量设定点无关。总体而言，研究结果表明，CD 8（+）T-EMRA细胞具有上级抗病毒活性，并表明在定义对HIV-1的保护性免疫特征时，需要考虑CD 8（+）T细胞应答的定性和定量方面。
CD8(+) T cells are believed to play an important role in the control of human immunodeficiency virus type 1 (HIV-1) infection. However, despite intensive efforts, it has not been possible to consistently link the overall magnitude of the CD8(+) T-cell response with control of HIV-1. Here, we have investigated the association of different CD8(+) memory T-cell subsets responding to HIV-1 in early infection with future control of HIV-1 viremia. Our results demonstrate that both a larger proportion and an absolute number of HIV-1-specific CD8(+) CCR7(-) CD45RA(+) effector memory T cells (T-EMRA cells) were associated with a lower future viral load set point. In contrast, a larger absolute number of HIV-1-specific CD8(+) CCR7(-) CD45RA(-) effector memory T cells (T-EM) was not related to the viral load set point. Overall, the findings suggest that CD8(+) T-EMRA cells have superior antiviral activity and indicate that both qualitative and quantitative aspects of the CD8(+) T-cell response need to be considered when defining the characteristics of protective immunity to HIV-1.