HUMAN BRAIN-TUMORS - SPECTRAL PATTERNS DETECTED WITH LOCALIZED H-1 MR SPECTROSCOPY
HUMAN BRAIN-TUMORS - SPECTRAL PATTERNS DETECTED WITH LOCALIZED H-1 MR SPECTROSCOPY
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DOI：
10.1148/radiology.183.3.1584924
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发表时间：
1992-06-01
期刊：
影响因子：
19.7
通讯作者：
FRIEDMANN, G
中科院分区：
文献类型：
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作者：
KUGEL, H;HEINDEL, W;FRIEDMANN, G
图像引导的局部质子磁共振（MR）光谱颅内肿瘤进行相关的光谱模式和组织学发现。36例患者在任何特定治疗前接受检查。基于信号强度比的评估显示，所有肿瘤谱都与健康脑组织的谱不同。与对侧大脑半球正常组织相比，所有肿瘤光谱中肌酸与含胆碱化合物（Cr/Cho）和乙酰天冬氨酸氮与Cho （NAA/Cho）的比值均显著降低（P < 0.005）。非脑肿瘤典型表现为NAA信号消失或缺失，Cr信号强烈减少，脑膜瘤中丙氨酸和转移瘤中的脂质有附加信号。11例2级和3级胶质瘤的NAA/Cho比值和Cr/Cho比值低于正常值，但显著高于8例脑膜瘤的相应值（P < 0.01）。10个胶质母细胞瘤表现出不同信号比的光谱，因此与其他肿瘤类型无明显差异。在9个胶质瘤中可明显检测到乳酸信号。然而，乳酸水平与组织学肿瘤分级没有直接关系。
Image-guided localized proton magnetic resonance (MR) spectroscopy of intracranial tumors was performed to correlate spectral patterns and histologic findings. Thirty-six patients were examined prior to any specific treatment. Evaluation based on signal intensity ratios showed that all tumor spectra differed from spectra of healthy brain tissue. Ratios of creatine to choline-containing compounds (Cr/Cho) and nitrogen acetyl-aspartate to Cho (NAA/Cho) were reduced significantly in all tumor spectra compared with spectra of normal tissue in contralateral brain hemispheres (P < .005). Noncerebral tumors typically showed a vanishing or missing NAA signal, strongly reduced Cr signal, and additional signals, assigned to alanine in meningiomas and lipids in metastases. In contrast, 11 gliomas of grades 2 and 3 exhibited NAA/Cho ratios and Cr/Cho ratios that were less than normal but that were significantly larger (P < .01) than corresponding values in eight meningiomas. Ten glioblastomas displayed spectra with various signal ratios, so no significant differences between them and other tumor types could be established. In nine gliomas a clearly detectable lactate signal was present. However, no direct correlation between lactate level and histologic tumor grading was found.