Neural mechanisms of atrial fibrillation.
Neural mechanisms of atrial fibrillation.
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DOI：
10.1097/hco.0b013e32834dc4e8
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发表时间：
2012-01
影响因子：
2.3
通讯作者：
Chen PS
中科院分区：
文献类型：
--
作者：
Park HW;Shen MJ;Lin SF;Fishbein MC;Chen LS;Chen PS
自主神经系统是心房颤动(房颤)发生和持续的潜在的强有力的调节器。本文将对房颤的神经机制作一简要综述。交感神经系统和副交感神经系统之间存在复杂的相互作用，影响心房电生理特性。在犬模型上的直接自主神经记录显示，交感迷走神经同时放电是阵发性房性心动过速和阵发性房颤最常见的触发因素。心脏内源性自主神经也是房颤发生的唯一触发因素。通过电刺激调节自主神经系统(ANS)已被临床和实验尝试作为一种治疗策略。最近的研究表明，自主神经调节可以抑制星状神经节神经活动，减少阵发性房性快速性心律失常的发生。自主神经系统影响房颤的发生和持续。在更好地了解ANS不同组成部分之间的复杂相互关系方面的科学进步将有望导致这种常见心律失常的治疗方法的改进。
The autonomic nerve system is a potentially potent modulator of the initiation and perpetuation of atrial fibrillation (AF). This review will briefly summarize the neural mechanisms of AF. Complex interactions exist between the sympathetic and parasympathetic nervous system on the atrial electrophysiologic properties. Direct autonomic recordings in canine models demonstrated simultaneous sympathovagal discharges are the most common triggers of paroxysmal atrial tachycardia and paroxysmal AF. Also, intrinsic cardiac autonomic nerve can serve as a sole triggering factor for the initiation of AF. Modulation of autonomic nervous system (ANS) by electrical stimulation has been tried as a treatment strategy clinically and experimentally. Recent studies showed that autonomic nervous system modulation can suppress the stellate ganglion nerve activity and reduce the incidence of paroxysmal atrial tachyarrhythmias in ambulatory dogs. The autonomic nerve system influences the initiation and perpetuation of AF. Scientific advances toward a better understanding of the complex interrelationships of the various components of the ANS will hopefully lead to improvement of treatments for this common arrhythmia.