Programmable Emulsions via Nucleophile-Induced Covalent Surfactant Modifications
Programmable Emulsions via Nucleophile-Induced Covalent Surfactant Modifications
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DOI：
10.1021/acs.chemmater.0c01107
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发表时间：
2020-06-09
影响因子：
8.6
通讯作者：
Thayumanavan, S.
中科院分区：
文献类型：
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作者：
Fernandez, Ann;Zentner, Cassandra A.;Thayumanavan, S.
采用动力学控制设计的响应表面活性剂很少见，为生成可调节反应组件提供了新的机会。在这项工作中，我们讨论了基于共价可触发表面活性剂的新型分子组装体的设计，该表面活性剂编程专门响应亲核触发器以引起界面改变。通过正式的 S(N)2' 型迈克尔加成化学，单乳液和动态双乳液界面处的这些诱发变化可以通过各种小分子亲核试剂和功能化纳米组装体进行动力学调节和引起，从而引起宏观响应，例如破裂或形态变化。此外，单独的响应模式可用于进一步控制乳液系统，以实现级联触发行为和程序化释放应用。
Responsive surfactants designed with kinetic control are rare and offer new opportunities in generating tunable reactive assemblies. In this work, we discuss the design of novel molecular assemblies based on covalently triggerable surfactants programmed to respond exclusively to nucleophilic triggers to cause interfacial alterations. Through a formal S(N)2'-type Michael addition chemistry, these induced alterations at the interface of single and dynamic double emulsions can be kinetically tuned and brought about by various small molecule nucleophiles and functionalized nanoassemblies to cause macroscopic responses, such as bursting or morphology changes. In addition, separate responsive modalities can be used to further control the emulsion systems to enable cascade trigger behavior and programmed release applications.