COMMON TOPOLOGY WITHIN A NONCOLLAGENOUS DOMAIN OF SEVERAL DIFFERENT COLLAGEN TYPES
COMMON TOPOLOGY WITHIN A NONCOLLAGENOUS DOMAIN OF SEVERAL DIFFERENT COLLAGEN TYPES
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DOI：
10.1016/0945-053x(94)90187-2
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发表时间：
1994-04-01
期刊：
影响因子：
6.9
通讯作者：
VANDERREST, M
中科院分区：
文献类型：
--
作者：
MORADIAMELI, M;DELEAGE, G;VANDERREST, M
使用不同的算法分析α（V）、α 1（XI）、α 1（IX）、α 1（XII）、α 1（XIV）和α 1（XVI）胶原蛋白链中以及富含脯氨酸和脯氨酸的蛋白质中保守的非胶原蛋白模块的二级结构。结果预测，在这些非胶原模块中存在由9个共有β链组成的共同反平行β折叠结构。提出了一个模型，这些β-折叠的包装，这表明预测的β-折叠结构可能涉及分子识别功能。
The secondary structure of a conserved non-collagenous module in alpha(V), alpha 1(XI), alpha 1(IX), alpha 1(XII), alpha 1(XIV) and alpha 1(XVI) collagen chains and in proline- and arginine-rich protein was analyzed using different algorithms. The results predict that a common anti-parallel beta-sheet structure composed of nine consensus beta-strands is present in these non-collagenous modules. A model for the packing of these beta-sheets is proposed which suggests that the predicted beta-sheet structure may be involved in molecular recognition functions.