Very long-chain saturated fatty acids and diabetes and cardiovascular disease.
Very long-chain saturated fatty acids and diabetes and cardiovascular disease.
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DOI：
10.1097/mol.0000000000000806
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发表时间：
2022-02-01
影响因子：
4.4
通讯作者：
King IB
中科院分区：
文献类型：
--
作者：
Lemaitre RN;King IB
与其他饱和脂肪酸相比，甚长链饱和脂肪酸（vlsfa）受到的关注有限。本综述的目的是总结vlsfa，包括花生四烯酸、behenic酸和木甘酸，与心血管疾病结局和2型糖尿病的关系；讨论研究结果的意义；并呼吁对vlsfa进行进一步的研究。研究发现，循环vlsfa水平升高与心衰、心房颤动、冠心病、死亡率、心脏骤停、2型糖尿病的发生风险降低有关，并与较好的衰老有关。携带VLSFA的血浆神经酰胺和鞘磷脂种类与心力衰竭、房颤和死亡率风险较低的关联是平行的，这表明VLSFA影响神经酰胺和鞘磷脂的生物活性，从而影响健康。对于糖尿病，没有这样的相似之处，vlsfa与糖尿病的关联可能被甘油三酯和循环棕榈酸所混淆或介导，甘油三酯和循环棕榈酸可能是新生脂肪生成的生物标志物。在许多方面，流行病学早于我们对vlsfa生物学的了解。我们希望这篇综述能激发研究界对进一步研究这些潜在有益脂肪酸的兴趣。
In contrast to other saturated fatty acids, very long-chain saturated fatty acids (VLSFAs) have received limited attention The purpose of this review is to summarize the associations of VLSFAs, including arachidic acid, behenic acid, and lignoceric acid, with cardiovascular disease outcomes and type 2 diabetes; to discuss the findings implications; and to call for future studies of the VLSFAs. Increased levels of circulating VLSFAs have been found associated with lower risks of incident heart failure, atrial fibrillation, coronary heart disease, mortality, sudden cardiac arrest, type 2 diabetes, and with better aging. The VLSFA associations are paralleled by associations of plasma ceramide and sphingomyelin species carrying a VLSFA with lower risks of heart failure, atrial fibrillation, and mortality, suggesting VLSFAs affect the biological activity of ceramides and sphingomyelins thereby impacting health. For diabetes, there is no such parallel and the associations of VLSFAs with diabetes may be confounded or mediated by triglyceride and circulating palmitic acid, possible biomarkers of de novo lipogenesis. In many ways, the epidemiology has preceded our knowledge of VLSFAs biology. We hope this review will spur interest from the research community in further studying these potentially beneficial fatty acids.