Eicosanoids and radiation.
Eicosanoids and radiation.
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类二十烷酸和辐射。
DOI：
10.1016/0959-8049(95)00327-f
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Hanson,WR
中科院分区：
文献类型：
--
作者：
Milas,L;Hanson,WR
放射治疗期间可以给予的最大辐射剂量取决于辐射场内关键正常组织的耐受性。因此，任何提高放疗疗效的尝试都必须以增加肿瘤放射反应和/或减少正常组织并发症为目标。为了实现这一目标，人们研究了许多不同的方法，包括调节正常组织和肿瘤中类二十烷酸的水平，尤其是前列腺素 (PC)。类二十烷酸是针对各种细胞损伤而产生的，并且外源性类二十烷酸已被证明可以调节多种药物引起的损伤。因此，推断它们参与电离辐射造成的组织损伤是合乎逻辑的。在过去 20 年中，人们对类二十烷酸（主要是 PG）在辐射损伤中的作用进行了大量研究。已经尝试通过施用外源性PG或抑制内源性PG来调节正常组织损伤。还进行了其他研究，通过调节肿瘤中的 PG 水平来增加肿瘤对辐射的反应。本概述考虑了类二十烷酸在辐射损伤的表达和改变中的作用的主要发现，特别强调了其治疗潜力。
THE MAXIMUM dose of radiation that can be given during radiotherapy depends on the tolerance of the critical normal tissue within the radiation field. Consequently, any attempt to improve the efficacy of radiotherapy must be aimed at increasing tumour radioresponse and/or reducing normal tissue complications. To achieve this objective, many diverse approaches have been investigated, including modulation of levels of eicosanoids, especially prostaglandins (PCs), in both normal tissues and tumours.Eicosanoids are produced in response to a variety of cellular injuries, and exogenous eicosanoids have been shown to modulate injury induced by a wide array of agents. Therefore, it was logical to infer their involvement in tissue injury by ionising radiation. During the past 20 years, there has been significant research into the role of eicosanoids, primarily PGs, in radiation damage. Attempts have been made to modulate normal tissue damage by administering exogenous PGs or inhibiting endogenous PGs. Other studies have been conducted to increase tumour response to radiation by modulating PG levels in tumours. This overview considers major fmdings on the role of eicosanoids in the expression and modification of radiation damage, with special emphasis on its therapeutic potential.