Clock genes and gastric cancer
Clock genes and gastric cancer
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时钟基因与胃癌
DOI：
10.1080/09291016.2021.2020993
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发表时间：
2022-01
影响因子：
1.1
通讯作者：
Dahu Chen
中科院分区：
文献类型：
--
作者：
Shuaishuai Cui;Yibing Chen;Yong Guo;Dahu Chen
昼夜节律是指以24小时为周期的心理、生理和行为变化，这种对光和暗的反应影响着大多数生物，包括动物、植物和微生物。生物钟由特定的分子（时钟基因）组成，这些分子与全身的细胞相互作用，是生物体用来调节昼夜节律的计时装置。在人类胃肠道中已经观察到昼夜节律。为此，基础胃酸产生、上皮细胞增殖、胃肠动力和食欲调节随一天中的时间而变化。生物钟基因的异常表达可以改变正常的昼夜节律，从而导致包括癌症在内的各种疾病。本研究旨在探讨和总结生物钟基因的表达与胃癌发生发展的关系，并探讨将其作为胃癌患者预后的生物标志物的可能性。缩略语：- 你好视黄酸相关孤儿受体反应元件; CLOCK：昼夜运动输出周期kaput; BMAL 1：脑和肌肉ARNT样蛋白1; ARNTL：芳香烃受体核转位样蛋白; PER：周期; CRY：隐花色素; mTOR：哺乳动物雷帕霉素靶蛋白; VNTR：可变数目串联重复序列; cAMP/PKA：环磷酸腺苷/蛋白激酶A通路
ABSTRACT The mental, physical and behavioural changes that follow a 24-hour cycle are defined as circadian rhythms, and this response to light and dark affects most living things, including animals, plants and microbes. Biological clocks are composed of specific molecules (clock genes) that interact with cells throughout the body and are the timing devices that organisms use to regulate circadian rhythms. Circadian rhythms have been observed in the human gastrointestinal tract. To this end, basal gastric acid production, epithelial cell proliferation, gastrointestinal motility and appetite regulation vary with the time of day. The abnormal expression of clock genes can alter normal circadian rhythms and subsequently cause a variety of illnesses, including cancers. The aim of this study was to discuss and summarize the relationship between the expression of clock genes and the development and progression of gastric cancer and to explore the possibility of using these genes as biomarkers in gastric cancer prognosis in patients. Abbreviations: RORE: retinoic acid-related orphan receptor response element; CLOCK: circadian locomotor output cycles kaput; BMAL1: brain and muscle ARNT-like protein 1; ARNTL: aryl hydrocarbon receptor nuclear translocator-like; PER: period; CRY: cryptochrome; mTOR: mammalian target of rapamycin; VNTR: variable number tandem repeat; cAMP/PKA: cyclic adenosine monophosphate/protein kinase A pathway
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影响因子：
3
作者：
A. Boddie;C. McBride;C. Balch
通讯作者：
A. Boddie;C. McBride;C. Balch
影响因子：
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影响因子：
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通讯作者：
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影响因子：
168.9
作者：
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通讯作者：
P. Hohenberger;S. Gretschel