Age-related decline in dopamine transporters: analysis of striatal subregions, nonlinear effects, and hemispheric asymmetries.
Age-related decline in dopamine transporters: analysis of striatal subregions, nonlinear effects, and hemispheric asymmetries.
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DOI：
10.1097/00019442-200201000-00005
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
C. V. van Dyck;J. Seibyl;R. Malison;M. Laruelle;S. Zoghbi;R. Baldwin;R. Innis
中科院分区：
文献类型：
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作者：
C. V. van Dyck;J. Seibyl;R. Malison;M. Laruelle;S. Zoghbi;R. Baldwin;R. Innis
神经影像学研究已经证明纹状体多巴胺转运蛋白（DAT）的年龄相关性下降是多巴胺能神经变性的标志。作者进一步阐明了与帕金森病（PD）相比，健康老龄化对该神经系统的影响。在一个大型健康受试者样本（N=126）中，使用[123 I] 2 β-甲氧羰基-3 β-（4-碘苯基）托烷（[123 I]beta-CIT）和单光子发射计算机断层扫描（SPECT）检查了年龄对纹状体DAT可用性的影响。纹状体DAT可用性（V3”）与年龄呈显著负相关，在18至88岁的年龄范围内以几乎线性的方式下降46%，或每十年下降6.6%。尾状核（48%）和壳核（45%）的下降率相当，随着年龄的增长，左右不对称性仅略有增加。半球不对称与受试者的用手习惯无关。这些结果表明，衰老与两个半球的尾状核和壳核中DAT的相对对称损失有关。这些发现不仅对健康老龄化有意义，而且对神经退行性疾病如PD也有意义。
Neuroimaging studies have documented an age-related decline in striatal dopamine transporters (DATs) as a marker of dopaminergic neurodegeneration. The authors further elucidated the effects on this neural system in healthy aging, in contrast to Parkinson disease (PD). The effects of age on striatal DAT availability were examined in a large, healthy subject sample (N=126) with [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane ([123I]beta-CIT) and single photon emission computed tomography (SPECT). Striatal DAT availability (V3") showed a significant inverse correlation with age, declining in a nearly linear manner by 46% over the age range 18 to 88 years, or 6.6% per decade. Rates of decline were comparable for caudate (48%) and putamen (45%), with only minimal increase in left-right asymmetry with age. Hemispheric asymmetries were unrelated to the handedness of subjects. These results demonstrate that aging is associated with a relatively symmetric loss of DATs in the caudate and putamen in both hemispheres. These findings have implications not only for healthy aging but also for neurodegenerative disorders such as PD.