Clinical application of growth factors and cytokines in wound healing.
Clinical application of growth factors and cytokines in wound healing.
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DOI：
10.1111/wrr.12205
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发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Tomic-Canic M
中科院分区：
文献类型：
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作者：
Barrientos S;Brem H;Stojadinovic O;Tomic-Canic M
伤口愈合是一个复杂而动态的生物学过程，涉及多种细胞类型的协调努力，并由许多生长因子和细胞因子执行和调节。在过去的二十年中，一直在研究各种生长因子在不愈合伤口（例如，压力性溃疡、慢性静脉溃疡、糖尿病足溃疡）的临床管理中的治疗效果。在这篇综述中，我们对Medline和Pub Medical进行了非线性检索，并对有关生长因子和细胞因子在这些伤口管理中的作用的文献进行了批判性分析。我们专注于目前批准的疗法，新兴疗法和未来的研究可能性。在这篇综述中，我们讨论了四种生长因子和细胞因子，目前正在使用的标签和标签外的伤口愈合。其中包括：粒细胞-巨噬细胞集落刺激因子（GM-CSF）、血小板衍生生长因子（PDGF）、血管内皮生长因子（VEGF）和碱性成纤维细胞生长因子（bFGF）。虽然使用生长因子和细胞因子的临床结果令人鼓舞，但许多研究涉及的样本量较小，并且测量的终点不同。因此，需要进一步的研究来提供疗效的确切证据。
Wound healing is a complex and dynamic biological process that involves the coordinated efforts of multiple cell types and is executed and regulated by numerous growth factors and cytokines. There has been a drive in the past two decades to study the therapeutic effects of various growth factors in the clinical management of non-healing wounds (e.g. pressure ulcers, chronic venous ulcers, diabetic foot ulcers). For this review, we conducted a nonline search of Medline and Pub Medical and critically analyzed the literature regarding the role of growth factors and cytokines in the management of these wounds. We focused on currently approved therapies, emerging therapies and future research possibilities. In this review we discuss four growth factors and cytokines currently being used on and off label for the healing of wounds. These include: granulocyte-macrophage colony stimulating factor (GM-CSF), platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF). While the clinical results of using growth factors and cytokines are encouraging, many studies involved a small sample size and are disparate in measured endpoints. Therefore, further research is required to provide definitive evidence of efficacy.