Development of a PET detector system compatible with MRI/NMR systems
Development of a PET detector system compatible with MRI/NMR systems
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DOI：
10.1109/23.596982
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发表时间：
1997-06-01
影响因子：
1.8
通讯作者：
Garlick, PB
中科院分区：
文献类型：
--
作者：
Shao, Y;Cherry, SR;Garlick, PB
我们报告的原型正电子发射断层扫描（PET）扫描仪兼容临床磁共振成像（MRI）扫描仪和核磁共振（NMR）光谱仪的发展。该单片PET系统由72个2x2 x5 mm氧硅酸镥（LSO）晶体组成，晶体通过2 mm直径、4米长的双包层光纤耦合到屏蔽在铝封闭件内的三个多通道光电倍增管（MC-PMT）。环直径为54 mm，切片厚度类似于1 mm FWHM。点源测量表明，该系统的重建分辨率为2.1mm，符合时间分辨率为26 ns，典型能量分辨率为45%。同时采集的PET和MR体模图像未显示显著伪影或失真。我们还从离体灌注的大鼠心脏中获得了同步核磁共振光谱和PET图像，证明了在生物系统中获得时间相关的PET和核磁共振信息的能力。同样，尽管9.4T的高场强，PET或NMR数据中没有明显的伪影。未来的挑战是扩大设计规模，开发出一种高分辨率、高灵敏度的设备，可用于体内系统的同步PET和MR研究。
We report the development of a prototype positron emission tomography (PET) scanner compatible with clinical magnetic resonance imaging (MRI) scanners and nuclear magnetic resonance (NMR) spectrometers. This single slice PET system consists of 72 2x2x5 mm lutetium oxyorthosilicate (LSO) crystals coupled by 2 mm diameter, 4 meter long double clad optical fibers to three multi-channel photomultiplier tubes (MC-PMT's) shielded inside an aluminum closure. The ring diameter is 54 mm and the slice thickness is similar to 1 mm FWHM. Measurements with a point source demonstrate that this PET system has a reconstructed resolution of 2.1 mm, a coincidence time resolution of 26 ns and a typical energy resolution of 45%. Simultaneously acquired PET and MR phantom images show no significant artifacts or distortions. We also obtained simultaneous NMR spectra and PET images from an isolated, perfused rat heart, demonstrating the power of obtaining temporally correlated PET and NMR information in biological systems. Again, no artifacts in the PET or NMR data were apparent, despite the high field strength of 9.4T. The challenge for the future is to scale up the design to develop a high resolution, high sensitivity device that can be used in simultaneous PET and MR studies of in vivo systems.