No association between telomere length and survival among the elderly and oldest old
No association between telomere length and survival among the elderly and oldest old
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DOI：
10.1097/01.ede.0000199436.55248.10
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发表时间：
2006-03-01
期刊：
影响因子：
5.4
通讯作者：
Christensen, K
中科院分区：
文献类型：
--
作者：
Bischoff, C;Petersen, HC;Christensen, K
背景：端粒长度与培养细胞的复制潜力之间存在负相关性，以及人类许多不同组织中端粒长度随着年龄的增长而减少的一致发现，表明端粒在体内细胞衰老中发挥作用，最终甚至在有机体衰老中发挥作用。此外，一项针对老年人的小型纵向研究表明，较长的端粒与较好的生存率相关。 方法：端粒长度是对 1997 年至 1998 年参与人口调查的 812 名年龄在 73 岁至 101 岁之间的人的血细胞平均末端限制性片段长度进行测量。参与者中有 652 名双胞胎。通过丹麦民事登记系统对参与者进行随访，直至 2005 年 1 月，当时有 412 名参与者 (51%) 死亡。 结果：单变量 Cox 回归分析显示，较长的端粒与较好的存活率相关（男性每 1 kb 的风险比 = 0.89 [95% 置信区间 = 0.76-1.04]，男性每 1 kb 的风险比为 0.79 [0.72-0.88]）。分别为女性）。然而，将年龄纳入分析后，估计值分别变为 0.97 (0.83-1.14) 和 0.93 (0.85-1.03)。配对内比较显示，在 175 对双胞胎中，至少有一对在随访期间死亡，其中 97 对 (55%) 中端粒长度较短的双胞胎首先死亡（95% 置信区间 = 48-63%）。我们无法证实最近报道的端粒长度与肥胖之间或端粒长度与吸烟之间的负相关性。结论：这项针对老年人和高龄老人的纵向研究并不支持这样的假设：一旦年龄得到控制，端粒长度是剩余寿命的预测因子。
Background: The consistent findings of a negative correlation between telomere length and replicative potential of cultured cells, as well as a decreasing telomere length in a number of different tissues in humans with age, have led to the suggestion that telomeres play a role in cellular aging in vivo and ultimately even in organismal aging. Furthermore, one small longitudinal study of elderly individuals has suggested that longer telomeres are associated with better survival.Methods: Telomere length was measured as mean terminal restriction fragment length on blood cells from 812 persons, age 73 to 101 years, who participated in population-based surveys in 1997-1998. Among the participants were 652 twins. The participants were followed up through the Danish Civil Registration system until January 2005, at which time 412 (51%) were dead.Results: Univariate Cox regression analyses revealed that longer telomeres were associated with better survival (hazard ratios = 0.89 [95% confidence interval = 0.76-1.04] per 1 kb in males and 0.79 [0.72-0.88] per 1 kb in females, respectively). However, including age in the analyses changed the estimates to 0.97 (0.83-1.14) and 0.93 (0.85-1.03), respectively. Intrapair comparison showed that among 175 twin pairs in which at least one died during follow up, it was the twin with the shorter telomere length who died first in 97 (55%) of the pairs (95% confidence interval = 48-63%). We could not confirm the recently reported negative correlation between telomere length and obesity or between telomere length and smoking.Conclusion: This longitudinal study of the elderly and oldest old does not support the hypothesis that telomere length is a predictor for remaining lifespan once age is controlled for.