INCREASED ADRENOCORTICAL ACTIVITY IN NEONATAL RAT FOLLOWING HANDLING
INCREASED ADRENOCORTICAL ACTIVITY IN NEONATAL RAT FOLLOWING HANDLING
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DOI：
10.1210/endo-81-5-1047
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发表时间：
1967-01-01
期刊：
影响因子：
4.8
通讯作者：
ZARROW, MX
中科院分区：
文献类型：
--
作者：
DENENBERG, VH;BRUMAGHIM, JT;ZARROW, MX
对2日龄大鼠采用标准处理程序，在幼仔返回母笼和母体后1/2小时，导致血浆皮质酮显著升高。该程序包括将幼仔从分娩笼中取出，将其单独放入部分填充有刨花的1加仑罐中，将其在罐中静置3分钟，然后将幼仔放回分娩笼。另外两个程序，处理技术的变体，也引起了显著的肾上腺皮质反应：第一个是将幼仔单独放在处理罐中33分钟，第二个是将幼仔放入空的产妇箱中1/2小时，通常在处理罐中3分钟后。最后的实验表明，如果将幼鼠置于保持在35.5 ℃的处理罐中，可以防止皮质酮反应。
A standard handling procedure, employed with 2-day-old rats, caused a significant rise in plasma corticosterone 1/2 hr after the pups were returned to the maternity cage and the mother. This procedure consists of removing the pups from the maternity cage, placing them individually into 1-gallon cans partially filled with shavings, leaving them undisturbed in the cans for 3 min.and then returning the pups to the maternity cage. Two other procedures, variants on the handling technique, also evoked a significant adrenocortical response: The first was to leave the pups alone in handling cans for 33 min, the second was to place the pups into an empty maternity case for 1/2 hr. after the usual 3 min. in handling cans. The final experiment showed that the corticosterone response could be prevented if the pups were placed in handling cans maintained at 35.5 C.