Conversion of alpha-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women.
Conversion of alpha-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women.
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男性和女性的α-亚麻酸转化为棕榈酸、棕榈油酸、硬脂酸和油酸。
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
S. Wootton
中科院分区：
文献类型：
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作者：
G. Burdge;S. Wootton
本研究的目的是确定成年人是否可以将α-亚麻酸（18：3 n-3）中的碳再循环为饱和（SFA）和单不饱和（MUFA）脂肪酸。六名男性和六名女性摄入了700 mg [U-13 C]-18：3 n-3。在21天内收集血液，在24小时内收集呼吸。在血浆磷脂酰胆碱（PC）和三酰甘油（TAG）中检测到[13 C]标记的SFA和MUFA。总标记的脂肪酸纳入SFA和MUFA是5倍和25倍以上的PC比TAG在男性和女性，分别。[13 C]-16：0是两个馏分中的主要标记脂肪酸。男性SFA和MUFA的总[13 C]掺入量比女性高20%，与呼吸中标记的18：3 n-3作为13 CO2的回收率呈正相关（r（2）= 0.35，P<0.05）。这些结果表明，分配到β-氧化和碳循环的程度可能会调节18：3 n-3转化为长链脂肪酸的可用性。
The purpose of this study was to determine whether adult humans can recycle carbon from alpha-linolenic acid (18:3n-3) into saturated (SFA) and monounsaturated (MUFA) fatty acids. Six men and six women consumed 700 mg [U-13C]-18:3n-3. Blood was collected over 21 days and breath over 24h. [13C]-labelled SFA and MUFA were detected in plasma phosphatidylcholine (PC) and triacylglycerol (TAG). Total labelled fatty acid incorporation into SFA and MUFA was five- and 25-fold greater in PC than TAG in men and women, respectively. [13C]-16:0 was the major labelled fatty acid in both fractions. Total [13C] incorporation into SFA and MUFA was 20% greater in men than women, and related positively (r(2) = 0.35, P<0.05) to the fractional recovery of labelled 18:3n-3 as 13CO2 on breath. These results suggest that the extent of partitioning towards beta-oxidation and carbon recycling may regulate the availability of 18:3n-3 for conversion to longer-chain fatty acids.