Tracing paternal ancestry in mice, using the Y-linked, sex-determining locus, Sry.
Tracing paternal ancestry in mice, using the Y-linked, sex-determining locus, Sry.
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DOI：
10.1093/oxfordjournals.molbev.a040128
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发表时间：
1994-05
影响因子：
10.7
通讯作者：
B. Lundrigan;P. Tucker
中科院分区：
文献类型：
--
作者：
B. Lundrigan;P. Tucker
哺乳动物Y-连锁DNA序列的分子进化是特别感兴趣的，因为它们独特的遗传模式：大多数Y-连锁序列是从父亲到儿子克隆遗传。在这里，我们调查使用Y-连锁序列的系统发育推断。我们描述了一个515-bp的区域的比较分析，从男性性别决定基因座，Sry，在22鼠啮齿动物（亚科鼠科，鼠科），包括代表从9种小鼠，并从另外两个鼠属-Mastomys和Hylomyscus。种内群体间的序列差异百分比< 0.01%，种间差异百分比为0.19%-8.16%。我们的系统发育分析的12个小鼠类群导致在一个单一的最简约树，是高度一致的基于线粒体DNA和等位酶的同源性。基于Sry、线粒体DNA和等位酶的证据树支持：（1）Mus亚属的单系性;（2）Mus亚属属于古北界的一个类群。musculus、M. M. tubercus，M. spicilegus、刺梗霉M. Macedonicus和M. spretus）和东方群（M. cookii++，M. cervicolor和M. caroli）;（3）M. spicilegus和M. macedonicus和M. cookii和M.鹿色我们认为，Y染色体DNA序列代表了一个有价值的新来源的字符系统发育推断。
The molecular evolution of mammalian Y-linked DNA sequences is of special interest because of their unique mode of inheritance: most Y-linked sequences are clonally inherited from father to son. Here we investigate the use of Y-linked sequences for phylogenetic inference. We describe a comparative analysis of a 515-bp region from the male sex-determining locus, Sry, in 22 murine rodents (subfamily Murinae, family Muridae), including representatives from nine species of Mus, and from two additional murine genera--Mastomys and Hylomyscus. Percent sequence divergence was < 0.01% for comparisons between populations within a species and was 0.19%-8.16% for comparisons between species. Our phylogenetic analysis of 12 murine taxa resulted in a single most-parsimonius tree that is highly concordant with phylogenies based on mitochondrial DNA and allozymes. A total evidence tree based on the combined data from Sry, mitochondrial DNA, and allozymes supports (1) the monophyly of the subgenus Mus, (2) its division into a Palearctic group (M. musculus, M. domesticus, M. spicilegus, M. Macedonicus, and M. spretus) and an Oriental group (M. cookii++, M. cervicolor, and M. caroli), and (3) sister-group relationships between M. spicilegus and M. macedonicus and between M. cookii and M. cervicolor. We argue that Y-chromosome DNA sequences represent a valuable new source of characters for phylogenetic inference.