"Pinopodes" and implantation.
"Pinopodes" and implantation.
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DOI：
10.1023/a:1015455709833
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发表时间：
2002-05-01
影响因子：
8.2
通讯作者：
Enders, Allen
中科院分区：
文献类型：
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作者：
Lopata, Alex;Bentin-Ley, Ursula;Enders, Allen
Nilsson（1958）在其关于小鼠子宫表面的论文中开始了小鼠和大鼠子宫内膜的电子显微镜研究。然而，在这个和其他早期的子宫腔上皮细胞的透射电子显微镜（TEM）研究中，除了微绒毛外，没有提到表面的突起。Warren和Enders（1964）报告了延迟着床期间大鼠腔上皮细胞的外质突起，但忽略了这些结构。Nilsson（1966）在一项关于不同激素条件下大鼠子宫内膜表面突起发生的更详细研究中指出，突起和规则微绒毛到缺乏突起的不规则表面的变化表明子宫从着床前到着床状态的变化。Vokaer和Leroy（1962）已经证明大鼠子宫腔上皮细胞摄取台盼蓝，但直到对子宫腔表面进行一系列扫描电子显微镜（SEM）研究后，才重新引起对顶端突起的兴趣。Nilsson（1972）注意到大鼠子宫腔表面有“羊肚菌样”突起，并推测这种突起可能是分泌性的。Psychoyos和Mandon称这种投射为“海葵样”，并认为它们可能是内吞的，或者参与信息的双向传递。Bergstrom（1972）指出，在小鼠中，这种投射在预着床或延迟着床条件下与胚泡密切相关。Ferenczy等人在人子宫腔上皮细胞的SEM研究中报告了类似的投影。
Nilsson (1958) initiated electron microscopic studies of the endometrium of the mouse and rat with his paper on mouse uterine surfaces. However, in this and other early transmission electron microscopic (TEM) studies of uterine luminal epithelial cells, no mention was made of protrusions from the surface other than microvilli. Warren and Enders (1964) reported ectoplasmic protrusions from the luminal epithelial cells of the rat during delayed implantation but otherwise ignored these structures. In a more detailed study of the occurrence of the projections from the rat endometrial surface under different hormonal conditions, Nilsson (1966) noted that the change from projections and regular microvilli to an irregular surface lacking projections was indicative of changes from the preimplantation to implantation condition in the uterus. Vokaer and Leroy (1962) had demonstrated trypan blue uptake by the rat uterine luminal epithelium, but it was not until a series of scanning electron microscopic (SEM) studies of the uterine luminal surface that interest in the apical projections was rekindled. Nilsson (1972) noted “morel-like” projections from the rat uterine luminal surface and speculated that such projections might be secretory. Psychoyos and Mandon called such projections “sea—anemonae—like” and suggested that they might be endocytic or involved in passage of information in either direction. Bergstrom (1972) showed that in the mouse such projections could come into close association with the blastocyst in preimplanta-tion or delayed implantation conditions. Somewhat similar projections were reported in a SEM study of human uterine luminal epithelial cells by Ferenczy et al.