Eight functional polymorphisms in the estrogen receptor 1 gene and endometrial cancer risk: a meta-analysis.
Eight functional polymorphisms in the estrogen receptor 1 gene and endometrial cancer risk: a meta-analysis.
复制标题
雌激素受体 1 基因的八种功能多态性与子宫内膜癌风险：荟萃分析
DOI：
10.1371/journal.pone.0060851
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Yan J
中科院分区：
文献类型：
--
作者：
Zhou X;Gu Y;Wang DN;Ni S;Yan J
新出现的证据表明，雌激素受体1（ESR 1）基因的常见功能多态性可能对个体对子宫内膜癌的易感性产生影响，但个别发表的结果是不确定的。这项荟萃分析的目的是更精确地估计ESR 1基因的8个多态性与子宫内膜癌风险之间的关联。对PubMed、Embase、Web of Science和中国生物医学（CBM）数据库中2012年11月1日之前发表的出版物进行了文献检索。计算粗比值比（OR）和95%置信区间（CI）。使用STATA 12.0软件进行统计分析。纳入了13项病例对照研究，共纳入7，649例子宫内膜癌病例和16，855例健康对照。当所有符合条件的研究汇总到荟萃分析中时，结果表明PvuII（C>T）多态性与子宫内膜癌风险增加相关，尤其是在高加索人群中。rs3020314（C>T）多态性与子宫内膜癌风险增加之间也存在显著相关性。此外，rs 2234670（S/L）多态性可能降低子宫内膜癌的发病风险。XbaI（A>G）、Codon 325（C>G）、Codon 243（C>T）、VNTR（S/L）和rs 2046210（G>A）多态性与两组间无统计学意义。目前的荟萃分析表明，PvuII（C>T）和rs3020314（C>T）多态性可能是子宫内膜癌的危险因素，特别是在高加索人群中。
Emerging evidence indicates that common functional polymorphisms in the estrogen receptor 1 (ESR1) gene may have an impact on an individual’s susceptibility to endometrial cancer, but individually published results are inconclusive. The aim of this meta-analysis is to derive a more precise estimation of the associations between eight polymorphisms in the ESR1 gene and endometrial cancer risk. A literature search of PubMed, Embase, Web of Science and China Biology Medicine (CBM) databases was conducted on publications published before November 1st, 2012. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Statistical analyses were performed using the STATA 12.0 software. Thirteen case-control studies were included with a total of 7,649 endometrial cancer cases and 16,855 healthy controls. When all the eligible studies were pooled into the meta-analysis, the results indicated that PvuII (C>T) polymorphism was associated with an increased risk of endometrial cancer, especially among Caucasian populations. There were also significant associations between rs3020314 (C>T) polymorphism and an increased risk of endometrial cancer. Furthermore, rs2234670 (S/L) polymorphism may decrease the risk of endometrial cancer. However, no statistically significant associations were found in XbaI (A>G), Codon 325 (C>G), Codon 243 (C>T), VNTR (S/L) and rs2046210 (G>A) polymorphisms. The current meta-analysis suggests that PvuII (C>T) and rs3020314 (C>T) polymorphisms may be risk factors for endometrial cancer, especially among Caucasian populations.
登录
查看更多内容
影响因子：
2.6
作者：
Lundin, Eva;Wirgin, Isaac;Lukanova, Annekatrin;Afanasyeva, Yelena;Krogh, Vittorio;Axelsson, Tomas;Hemminki, Kari;Clendenen, Tess V.;Arslan, Alan A.;Ohlson, Nina;Sieri, Sabina;Roy, Nirmal;Koenig, Karen L.;Idahl, Annika;Berrino, Franco;Toniolo, Paolo;Hallmans, Goran;Foersti, Asta;Muti, Paola;Lenner, Per;Shore, Roy E.;Zeleniuch-Jacquotte, Anne
通讯作者：
Zeleniuch-Jacquotte, Anne
影响因子：
2.9
作者：
da Costa, Bruno R.;Cevallos, Myriam;Egger, Matthias
通讯作者：
Egger, Matthias
影响因子：
4.6
作者：
Safarinejad, Mohammad Reza;Safarinejad, Saba;Safarinejad, Shiva
通讯作者：
Safarinejad, Shiva
影响因子：
4.7
作者：
Yang, Hannah P.;Gonzalez Bosquet, Jesus;Garcia-Closas, Montserrat
通讯作者：
Garcia-Closas, Montserrat
DOI：
10.1016/s0006-291x(02)02248-9
发表时间：
2002-09-27
影响因子：
3.1
作者：
Sasaki, M;Tanaka, Y;Dahiya, R
通讯作者：
Dahiya, R