Oxytocin Mediates Entrainment of Sensory Stimuli to Social Cues of Opposing Valence.
Oxytocin Mediates Entrainment of Sensory Stimuli to Social Cues of Opposing Valence.
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DOI：
10.1016/j.neuron.2015.06.022
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发表时间：
2015-07-01
期刊：
影响因子：
16.2
通讯作者：
Choi GB
中科院分区：
文献类型：
--
作者：
Choe HK;Reed MD;Benavidez N;Montgomery D;Soares N;Yim YS;Choi GB
有意义的社会互动改变了对感官刺激的行为反应。中性感觉刺激夹带到显著的社会线索以产生社会学习的神经机制仍不清楚。我们使用气味驱动的行为范式来询问催产素，一种与各种社会行为有关的神经肽，是否在气味和有社会意义的线索之间形成习得的联系方面发挥关键作用。通过遗传、光遗传学和药理学操作，我们表明催产素受体信号对于气味对社会线索的夹带是至关重要的，但对于对非社会线索的夹带是必不可少的。此外，我们还证明了催产素直接影响梨状皮质，即嗅觉皮质，以调节社会学习。最后，我们提供了后叶催产素在渴望和厌恶社交学习中发挥作用的证据。这些结果表明，在气味驱动的社会学习过程中，催产素将社会刺激的显著传递到梨状皮质的感觉表征上。
Meaningful social interactions modify behavioral responses to sensory stimuli. The neural mechanisms underlying the entrainment of neutral sensory stimuli to salient social cues to produce social learning remains unknown. We used odor-driven behavioral paradigms to ask if oxytocin, a neuropeptide implicated in various social behaviors, plays a crucial role in the formation of learned associations between odor and socially significant cues. Through genetic, optogenetic and pharmacological manipulations, we show that oxytocin receptor signaling is crucial for entrainment of odor to social cues, but is dispensable for entrainment to non-social cues. Furthermore, we demonstrate that oxytocin directly impacts the piriform, the olfactory sensory cortex, to mediate social learning. Lastly, we provide evidence that oxytocin plays a role in both appetitive and aversive social learning. These results suggest that oxytocin conveys saliency of social stimuli to sensory representations in the piriform cortex during odor-driven social learning.