Differentiating the roles of the hippocampus and perirhinal cortex in processes beyond long-term declarative memory: A double dissociation in dementia
Differentiating the roles of the hippocampus and perirhinal cortex in processes beyond long-term declarative memory: A double dissociation in dementia
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DOI：
10.1523/jneurosci.3157-05.2006
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发表时间：
2006-05-10
影响因子：
5.3
通讯作者：
Graham, KS
中科院分区：
文献类型：
--
作者：
Lee, ACH;Buckley, MJ;Graham, KS
越来越多的证据表明，海马和嗅周皮层可能介导的过程超出了长期的陈述性记忆。我们评估了阿尔茨海默病（AD）或语义性痴呆（SD）患者的视觉古怪判断任务，没有明确的长期记忆的要求，是已知的海马和嗅周皮层病变敏感。重要的是，在内侧颞叶内，AD与主要的海马萎缩相关，而SD患者有更大的嗅周皮质损伤。AD组在对场景的奇异性判断上有选择性受损，而SD组仅在面部奇异性判断上有缺陷。这种令人信服的双重分离支持了这样一种观点，即海马体和嗅周皮层可能分别在感知或极短期工作记忆领域对场景和物体的处理至关重要。
There is increasing evidence to suggest that the hippocampus and perirhinal cortex may mediate processes beyond long-term declarative memory. We assessed patients with Alzheimer's disease (AD) or semantic dementia (SD) on a visual oddity judgment task that did not place an explicit demand on long-term memory and is known to be sensitive to hippocampal and perirhinal cortex lesions. Importantly, within the medial temporal lobe, AD is associated with predominant hippocampal atrophy, whereas SD patients have greater perirhinal cortex damage. The AD group was selectively impaired in oddity judgment for scenes, whereas the SD patients demonstrated a deficit in face oddity judgment only. This compelling double dissociation supports the idea that the hippocampus and perirhinal cortex may be critical for the processing of scenes and objects, respectively, in the domain of perception or very short-term working memory.