Pain characteristics and nicotine deprivation as predictors of performance during a laboratory paradigm of smoking cessation.
Pain characteristics and nicotine deprivation as predictors of performance during a laboratory paradigm of smoking cessation.
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疼痛特征和尼古丁剥夺作为实验室戒烟范例中表现的预测因素。
DOI：
10.1037/adb0000532
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Ditre,JosephW
中科院分区：
文献类型：
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作者：
Powers,JessicaM;LaRowe,LisaR;Heckman,BryanW;Ditre,JosephW
虽然吸烟者与共同发生的疼痛报告的期望经历更大的尼古丁戒断和戒烟困难，有限的工作已经审查了戒烟相关的结果疼痛的作用。本研究的目的是检查临床相关的疼痛特征（疼痛持续性，疼痛强度，疼痛相关的残疾）作为戒断和吸烟失效/复吸结果的预测因素，使用实验室戒烟范例。参与者（N= 120名每日吸烟者; 48%为男性; M年龄= 36.17，SD= 12.16; M每天吸烟= 20.51，SD= 6.99）在实验研究访视前被随机分配至非剥夺或12小时尼古丁剥夺条件。到达实验室后，参与者完成了疼痛特征和尼古丁戒断症状的测量。主要结局包括尼古丁戒断评分和类似的吸烟失效（开始吸烟的潜伏期）和复吸（吸烟数量）。我们假设，具有更大疼痛持续性、疼痛强度和疼痛相关残疾的吸烟者将支持更严重的尼古丁戒断和更大的失效/复发行为，并且这些正相关性在尼古丁剥夺者中更强。结果表明，除了尼古丁剥夺的影响之外，持续性疼痛预示着更严重的尼古丁戒断，而在实验室范式中，与疼痛相关的残疾越大，预示着消失的潜伏期越快。与预期相反，尼古丁剥夺并没有缓和疼痛特征对戒断或复发/复发结局的影响。临床意义包括，不同的疼痛过程可能会影响不同的戒烟结果，并在疼痛的吸烟者可能会受益于提供药物援助，以更好地控制戒断症状。（PsycINFO数据库记录（c）2020阿帕，保留所有权利）
Although smokers with co-occurring pain report expectations for experiencing greater nicotine withdrawal and difficulty quitting, limited work has examined the role of pain in cessation-related outcomes. The goal of this study was to examine clinically relevant pain characteristics (pain persistence, pain intensity, pain-related disability) as predictors of withdrawal and smoking lapse/relapse outcomes using a laboratory paradigm of cessation. Participants (N= 120 daily cigarette smokers; 48% male; M age= 36.17, SD= 12.16; M Cigarettes Per Day= 20.51, SD= 6.99) were randomized to either nondeprived or 12-hr nicotine deprivation conditions prior to an experimental study visit. Upon arrival to the laboratory, participants completed measures of pain characteristics and nicotine withdrawal symptoms. Primary outcomes included nicotine withdrawal scores and analogues of smoking lapse (latency to initiating smoking) and relapse (number of cigarettes smoked). We hypothesized that smokers with greater pain persistence, pain intensity, and pain-related disability would endorse more severe nicotine withdrawal and greater lapse/relapse behavior, and that these positive associations would be stronger among those who were nicotine deprived. Results indicated that, above and beyond the effect of nicotine deprivation, persistent pain predicted more severe nicotine withdrawal, and that greater pain-related disability predicted quicker latency to lapse during the laboratory paradigm. Contrary to expectation, nicotine deprivation did not moderate effects of pain characteristics on withdrawal or lapse/relapse outcomes. Clinical implications include that different pain processes may influence different cessation outcomes, and that smokers in pain may benefit from the provision of pharmacological aids to better control withdrawal symptoms.(PsycINFO Database Record (c) 2020 APA, all rights reserved)