The emerging role of microRNAs in cardiac remodeling and heart failure.
The emerging role of microRNAs in cardiac remodeling and heart failure.
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DOI：
10.1161/circresaha.108.183087
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发表时间：
2008-11-07
影响因子：
20.1
通讯作者：
Mann DL
中科院分区：
文献类型：
--
作者：
Divakaran V;Mann DL
最近的研究表明，被称为microRNAs （miRNAs或miRs）的微小调控rna家族在控制健康和疾病中心脏功能的各个方面具有潜在的重要作用。尽管miRNA生物学领域相对较新，但越来越多的证据表明，miRNA可能通过调节调节适应性和非适应性心脏重构过程的基因表达水平，在心力衰竭的发病机制中发挥重要作用。在这里，我们回顾了miRNA在调节心脏重塑过程的各个方面的生物学作用，并讨论了miRNA生物学在心力衰竭领域的潜在应用。
Recent studies have suggested a potentially important role for a family of tiny regulatory RNAs, known as microRNAs (miRNAs or miRs), in the control of diverse aspects of cardiac function in health and disease. Although the field of miRNA biology is relatively new, there is emerging evidence that miRNAs may play an important role in the pathogenesis of heart failure through their ability to regulate the expression levels of genes that govern the process of adaptive and maladaptive cardiac remodeling. Here we review the biology of miRNAs in relation to their role in modulating various aspects of the process of cardiac remodeling, as well as discuss the potential application of miRNA biology to the field of heart failure.