SLC6 transporters: structure, function, regulation, disease association and therapeutics.
SLC6 transporters: structure, function, regulation, disease association and therapeutics.
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DOI：
10.1016/j.mam.2012.07.002
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发表时间：
2013-04
影响因子：
10.6
通讯作者：
Henry, L. Keith
中科院分区：
文献类型：
--
作者：
Pramod, Akula Bala;Foster, James;Carvelli, Lucia;Henry, L. Keith
SLC6家族二级活性转运蛋白是整体膜溶质载体蛋白，其特征是小氨基酸或氨基酸样底物的Na+依赖易位。SLC6转运蛋白，包括血清素、多巴胺、去甲肾上腺素、GABA、牛磺酸、肌酸以及氨基酸转运蛋白，与许多人类疾病和失调有关，使该家族成为治疗发展的关键靶点。此外，这个家庭的一些成员直接参与毒品滥用的行动，如可卡因，安非他明和摇头丸。最近的进展提供了对这个家族的结构洞察，极大地加快了我们研究这些蛋白质及其参与复杂生物过程的能力。
The SLC6 family of secondary active transporters are integral membrane solute carrier proteins characterized by the Na+-dependent translocation of small amino acid or amino acid-like substrates. SLC6 transporters, which include the serotonin, dopamine, norepinephrine, GABA, taurine, creatine, as well as amino acid transporters, are associated with a number of human diseases and disorders making this family a critical target for therapeutic development. In addition, several members of this family are directly involved in the action of drugs of abuse such as cocaine, amphetamines, and ecstasy. Recent advances providing structural insight into this family have vastly accelerated our ability to study these proteins and their involvement in complex biological processes.
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影响因子：
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通讯作者：
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影响因子：
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