HRRT Versus HR plus Human Brain PET Studies: An Interscanner Test-Retest Study
HRRT Versus HR plus Human Brain PET Studies: An Interscanner Test-Retest Study
复制标题
DOI：
10.2967/jnumed.108.058628
复制
发表时间：
2009-05-01
影响因子：
9.3
通讯作者：
Boellaard, Ronald
中科院分区：
文献类型：
--
作者：
van Velden, Floris H. P.;Kloet, Reina W.;Boellaard, Ronald
高分辨率研究断层扫描仪（HRRT）是一种专用的人脑PET扫描仪。本研究的目的是比较HRRT与临床HR+ PET扫描仪的定量准确性，并评估两种扫描仪之间空间分辨率差异的影响（HRRT和HR+分别类似于2.7 mm和7.0 mm）。方法：对7名健康志愿者的C-11-氟马西尼配对扫描进行评估。对于每名志愿者，在同一天在两台扫描仪上采集动态扫描（包括动脉采样），从而最大限度地减少受试者间的变异性。使用Logan图分析和血浆输入生成分布容积。此外，其他血浆输入、参考组织（以脑桥作为参考组织输入）和参数方法也包括在扫描仪间比较中。结果如下：HRRT数据的Logan分布容积分析显示值高于HR+数据（截距固定在原点的斜率为1.14 +/- 0.10至1.19 +/- 0.10，取决于所用的HRRT重建方法）。使用6 mm半峰全宽高斯核进行的平滑HRRT重建将该斜率降低至同一性线（1.04 +/- 0.11至1.07 +/- 0.11），保持HR+和HRRT数据之间的良好相关性（r，类似于0.98）。其他血浆输入、参考组织和参数方法也观察到类似趋势。然而，在参考匹配后，参考组织模型显示HRRT动力学参数值低于HR+值（固定截距的斜率，0.90 +/- 0.10至0.94 +/- 0.13）。结论：从HRRT与HR+ PET研究中获得的药代动力学参数值较高，表明HRRT PET定量改善，主要是由于部分容积效应减少。
The high-resolution research tomograph (HRRT) is a dedicated human brain PET scanner. The purpose of this study was to compare the quantitative accuracy of the HRRT with that of the clinical HR+ PET scanner and to assess effects of differences in spatial resolution between both scanners (similar to 2.7 mm and similar to 7.0 mm for HRRT and HR+, respectively). Methods: Paired C-11-flumazenil scans of 7 healthy volunteers were assessed. For each volunteer, dynamic scans (including arterial sampling) were acquired on both scanners on the same day, thereby minimizing intersubject variability. Volume of distribution was generated using Logan plot analysis with plasma input. In addition, other plasma input, reference tissue (with pons as the reference tissue input), and parametric methods were included in the inter-scanner comparison. Results: Logan volume-of-distribution analysis of HRRT data showed higher values than that of HR+ data (slope with the intercept fixed at the origin of 1.14 +/- 0.10 to 1.19 +/- 0.10, depending on the HRRT reconstruction method used). Smoothing HRRT reconstructions with a 6-mm full width at half maximum gaussian kernel reduced this slope toward the line of identity (1.04 +/- 0.11 to 1.07 +/- 0.11), retaining good correlation between HR+ and HRRT data (r, similar to 0.98). Similar trends were observed for other plasma input, reference tissue, and parametric methods. However, after reference matching the reference tissue models showed lower HRRT kinetic parameter values than HR+ values (slope with fixed intercept, 0.90 +/- 0.10 to 0.94 +/- 0.13). Conclusion: Higher values of pharmacokinetic parameter values, obtained from HRRT versus HR+ PET studies, indicate improved HRRT PET quantification primarily due to a reduction in partial-volume effects.