Genetic factors in physical activity levels - A twin study
Genetic factors in physical activity levels - A twin study
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DOI：
10.1016/s0749-3797(02)00478-6
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发表时间：
2002-08-01
影响因子：
5.5
通讯作者：
Beunen, G
中科院分区：
文献类型：
--
作者：
Maia, JAR;Thomis, M;Beunen, G
背景。青少年的体育参与和体力活动水平存在显着的个体差异。本研究的目的是（1）估计基因以及共享和非共享环境因素对运动参与指数（SPI）和休闲体育活动（LTPA）变化的相对贡献； (2) 测试这些因素在男性和女性中的差异。方法：样本由 411 对年龄在 12 至 25 岁的不同合性的葡萄牙双胞胎组成。 SPI 和 LTPA 通过 Baecke 问卷进行评估。使用定量遗传模型来测试替代模型是否存在加性基因效应 (a(2))、家族内共同或共享的环境 (c(2)) 以及独特的环境因素 (e(2))。 结果：最拟合的模型显示了两种表型的性别特异性效应。男性 SPI 的方差分量为 a(2)=68.4%、c(2)=20%、c(2)=11.6%；在女性中，a(2)=39.8%，c(2)=28.4%，c(2)=31.8%。对于LTPA的变异，男性遗传因素解释了63%，共同环境不显着，独特环境解释了37%。在女性中，影响因素为a(2)=32%、c(2)=38%和c(2)=30%。结论：遗传效应解释了SPI和LTPA的相当大的变异，其中男性比女性更大。 SPI 和 LTPA 中共享环境因素（家庭和同伴）和非共享环境因素的相关性在女性中尤其明显。
Background. Substantial interindividual variation is observed in sports participation and physical activity levels in youth. This study aimed to (1) estimate the relative contribution of genes, along with shared and nonshared environmental factors, to variation in sports participation index (SPI) and leisure-time physical activity (LTPA); and (2) test differences in those factors in males and females.Methods: The sample was comprised of 411 Portuguese twin pairs of different zygosity aged 12 to 25 years. The SPI and LTPA were assessed with the Baecke questionnaire. Quantitative genetic modeling was used to test alternative models for the presence of additive gene effects (a(2)), common or shared environment within the family (c(2)), and unique environmental factors (e(2)).Results: The best-fitting models showed sex-specific effects for the two phenotypes. Variance components for SPI in males were a(2)=68.4%, c(2)=20%, and c(2)=11.6%; and in females, a(2)=39.8%, c(2)=28.4%, and c(2)=31.8%. For variation in LTPA, genetic factors in males explained 63%, common environment was not significant, and unique environment explained 37%. In females, contributing factors were a(2)=32%, c(2)=38%, and c(2)=30%.Conclusions: Genetic effects explained a considerable amount of variation in SPI and LTPA, which were greater in males than in females. The relevance of shared environmental factors (family and peers) and nonshared environmental factors in SPI and LTPA is particularly evident in females.