Na+-dependent fructose transport via rNaGLT1 in rat kidney
Na+-dependent fructose transport via rNaGLT1 in rat kidney
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DOI：
10.1016/s0014-5793(03)00600-8
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发表时间：
2003-07-10
期刊：
影响因子：
3.5
通讯作者：
Inui, K
中科院分区：
文献类型：
--
作者：
Horiba, N;Masuda, S;Inui, K
We found a system of Na+-dependent uptake of fructose by rat renal brush-border vesciles. It consisted of two saturablen components and was thought to involve at least two transporters. rNaGLT1, a novel glucose transporter in rat kidney, showed fructose uptake as well as alpha-methyl-(D)-glucopyranoside uptake by transfected HEK293 cells. The features of the lower affinity type of fructose transporter in the brush-border membranes, such as affinity and substrate recognition, were very comparable with those of rNaGLT1-transfected HEK293 cells. These results inducated that rNaGLT1 is a primary fructose transporter in rat renal brush-border membranes. (C) 2003 Published by Elsevier Science B.V. on behalf ofthe Federation of European Biochemical Societies.
