A structural-energetic basis for B-cell epitope prediction
A structural-energetic basis for B-cell epitope prediction
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DOI：
10.2174/092986606777790502
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发表时间：
2006-01-01
影响因子：
1.6
通讯作者：
Caoili, Salvador Eugenio C.
中科院分区：
文献类型：
--
作者：
Caoili, Salvador Eugenio C.
对肽和蛋白抗原结合抗体的结构能分析揭示了抗肽抗体与蛋白交叉反应和抗蛋白抗体与肽交叉反应的根本区别，为b细胞表位预测提供了物理化学基础，并应用于肽基疫苗的开发和免疫诊断。
Structural-energetic analysis of peptide and protein antigens in the context of binding to antibody reveals fundamental differences between the cross-reactions of antipeptide antibody with protein and antiprotein antibody with peptide, providing a physicochemical basis for B-cell epitope prediction as applied to the development of peptide-based vaccines and immunodiagnostics.