PROARRHYTHMIC EFFECTS OF THE CLASS-III AGENT ALMOKALANT - IMPORTANCE OF INFUSION RATE, QT DISPERSION, AND EARLY AFTERDEPOLARIZATIONS
PROARRHYTHMIC EFFECTS OF THE CLASS-III AGENT ALMOKALANT - IMPORTANCE OF INFUSION RATE, QT DISPERSION, AND EARLY AFTERDEPOLARIZATIONS
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DOI：
10.1093/cvr/27.12.2186
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发表时间：
1993-12-01
影响因子：
10.8
通讯作者：
SCHILLERLINHARDT, G
中科院分区：
文献类型：
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作者：
CARLSSON, L;ABRAHAMSSON, C;SCHILLERLINHARDT, G
目的：探讨获得性长QT综合征尖端扭转型室性心动过速的发病因素。方法：对麻醉家兔或猫连续输注甲氧胺和III类药物阿莫卡兰（分别以5或25 nmol.kg（-1）.min（-1）的速率），并检查对尖端扭转型室性心动过速发生率和QT离散度的影响。本文还研究了阿莫卡兰对家兔和猫浦肯野纤维和心室肌细胞动作电位的影响。结果：“高速率”输注阿莫卡兰使QT（c）间期延长[从162（SEM 6.2）ms延长至211（5.3）ms，p
Objective: The aim was to study factors contributing to torsade de pointes in the acquired long QT syndrome. Methods: Anaesthetised rabbits or cats were given a continuous infusion of methoxamine and the class III agent almokalant (at a rate of 5 or 25 nmol.kg(-1).min(-1), respectively) and the effects on incidence of torsade de pointes and QT dispersion were examined. Effects of almokalant on action potentials recorded from Purkinje fibres and ventricular cells of rabbits and cats were also studied. Results: ''High rate'' infusion of almokalant prolonged the QT(c) interval [from 162(SEM 6.2) ms to 211(5.3) ms, p