Self-assembly of Cationic, Hetero- or Homo-nuclear Ru(II) Macrocyclic Rectangles and their Photophysical, Electrochemical and Biological Studies.
Self-assembly of Cationic, Hetero- or Homo-nuclear Ru(II) Macrocyclic Rectangles and their Photophysical, Electrochemical and Biological Studies.
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DOI：
10.1021/om200908c
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发表时间：
2011-12-12
期刊：
影响因子：
2.8
通讯作者：
Chi KW
中科院分区：
文献类型：
--
作者：
Vajpayee V;Song YH;Yang YJ;Kang SC;Cook TR;Kim DW;Lah MS;Kim IS;Wang M;Stang PJ;Chi KW
一系列的超分子矩形，包括两个混合金属钌/铂配合物，已形成的配位驱动的自组装的范围芳烃-Ru的“分子夹”受体（1a-1d）与刚性的联吡啶基配体（2a-2d）在溶液中超过10小时的过程。分离的产物通过多核NMR（1H和13 C或31 P）、HR-ESI-MS和X-射线衍射研究来表征，以支持归因的双组分矩形结构。通过UV-Vis和荧光研究进一步表征矩形。用循环伏安法测定了矩形3ca和3da的氧化还原行为。此外，测定了这组矩形化合物对多种人癌细胞系的抗肿瘤活性，其中配合物3ca、3da、3cb、3cc和3cd显示出显著的活性，IC 50值低至2.65 μM。
A series of supramolecular rectangles, including two mixed-metal Ru/Pt complexes, have been formed by the coordination-driven self-assembly of a range of arene-Ru “molecular clip” acceptors (1a-1d) with rigid dipyridyl-based ligands (2a-2d) over the course of 10 hours in solution. The isolated products were characterized by multinuclear NMR (1H and 13C or 31P), HR-ESI-MS and an X-ray diffraction study to support the ascribed two-component rectangular structures. The rectangles were further characterized by UV-Vis and fluorescence studies. The redox behaviors of rectangles 3ca and 3da were also determined using cyclic voltammetry. Additionally, the antitumor activities of the suite of rectangles were determined against various human cancer cell lines and significant activity was shown by complexes 3ca, 3da, 3cb, 3cc and 3cd, with IC50 values as low as 2.65 μM.
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