Biphasic-Scanning Ion Conductance Microscopy
Biphasic-Scanning Ion Conductance Microscopy
复制标题
双相扫描离子电导显微镜
DOI：
10.1021/acs.analchem.8b03660
复制
发表时间：
2018
影响因子：
7.4
通讯作者：
Baker, Lane A.
中科院分区：
文献类型：
--
作者：
Choi, Myunghoon;Baker, Lane A.
描述了一种用于扫描离子电导显微镜（SICM）的浓度梯度驱动成像机制。两种不同的溶液相，一种填充双筒移液管，一种在浴中，用于在非标准SICM条件下提供探针控制和成像。在这些条件下，不添加电解质的溶液可用作浴溶液。此外，正反馈和负反馈模式都表现为探头接近表面。我们称这种方法为双相SICM（BP-SICM）。本文描述了实现BP-SICM的技术细节和操作原理。
A concentration gradient driven imaging mechanism is described for scanning ion conductance microscopy (SICM). Two different solution phases, one filling a double-barrel pipet and one in the bath, are used to afford probe control and imaging under nonstandard SICM conditions. Under these conditions, solutions with no added electrolyte can be utilized as the bath solution. Further, both positive and negative feedback modes are exhibited as the probe approaches the surface. We term this method biphasic-SICM (BP-SICM). Technical details of implementing BP-SICM and operational principles are described herein.