A comparative study of BK and JC virus infections in organ transplant recipients
A comparative study of BK and JC virus infections in organ transplant recipients
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DOI：
10.1002/jmv.20442
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发表时间：
2005-10-01
影响因子：
12.7
通讯作者：
Weck, K
中科院分区：
文献类型：
--
作者：
Randhawa, P;Uhrmacher, J;Weck, K
JC病毒（JCV）很少引起肾脏疾病，而BK病毒（BKV）是病毒性肾病的已知原因。关于健康和移植受试者中JCV患病率的现有研究仅报告了病毒DNA的定性检测。我们使用定量PCR（qPCR）来评估移植受者和非免疫抑制对照组中的JC病毒载量，并将JCV载量与BKV载量进行比较。JC病毒尿见于8/23例（34.7%）对照、23/103例（22.3%）肾移植和10/44例（22.7%）肝移植患者。无患者发生JC病毒血症。BK病毒尿见于2/23（8.7%）例对照、36/103（34.9%）例肾移植和7/44（15.9%）例肝移植患者。BK病毒血症仅见于肾脏（8/103 = 7.7%）患者。肾脏中的平均BKV尿载量高于肝脏患者和对照组（4.22 E + 07 vs. 2.88 E + 05 vs. 4.39 E + 02拷贝/ ml），而所有三个患者组的JC病毒载量相似（1.55 E + 06 vs. 2.66 E + 06 vs. 2.13 E + 06拷贝/ml）。在研究的所有患者类别中，JCV病毒载量都惊人地高，但不会导致病毒血症或病毒性肾病。虽然BKV和JCV在接受移植的患者中广泛潜伏，但两种病毒的同时再活化并不常见。BKV病毒血症见于肾移植受者，而非肝移植受者。这些值得注意的现象背后的机制仍有待研究。
JC virus (JCV) rarely causes kidney disease, whereas BK virus (BKV) is a known cause of viral nephropathy. Existing studies on prevalence of JCV in healthy and transplanted subjects have reported only qualitative detection of viral DNA. We used quantitative PCR (qPCR) to assess JC viral load in transplant recipients and non-immunosuppressed controls, and compared JCV loads to BKV loads. JC viruria was seen in 8/23 (34.7%) controls, 23/103 (22.3%) renal, and 10/44 (22.7%) liver transplant patients. No patient developed JC viremia. BK viruria was seen in 2/23 (8.7%) controls, 36/103 (34.9%) renal, and 7/44 (15.9%) liver transplant patients. BK viremia was seen only in the kidney (8/103 = 7.7%) patients. The mean BKV urinary load was higher in kidney compared to liver patients and controls (4.22E + 07 vs. 2.88E + 05 vs. 4.39E + 02 copies/ ml), whereas JC viral load was similar for all three patient groups (1.55E + 06 vs. 2.66E + 06 vs. 2.13E + 06 copies/ml). JCV viral loads were surprisingly high in all patient categories studied, but did not result in viremia or viral nephropathy. Although both BKV and JCV are widely latent in patients accepted for transplantation, concurrent reactivation of both viruses was infrequent. BKV viremia was seen in kidney but not liver recipients. The mechanisms underlying these notable phenomena remain to be investigated.