Inositol polyphosphate kinases: regulators of nuclear function.
Inositol polyphosphate kinases: regulators of nuclear function.
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DOI：
10.1042/bss0740183
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发表时间：
2007-01
期刊：
影响因子：
--
通讯作者：
A. Seeds;J. York
中科院分区：
文献类型：
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作者：
A. Seeds;J. York
最近的工作发现了磷脂酶C激活和1，4，5-三磷酸肌醇下游的肌醇信号通路在调控核过程中的作用，包括基因表达、mRNA输出和DNA代谢。几种肌醇多聚磷酸酶(IPK)的鉴定重新引起了人们对肌醇四、五、六和焦磷酸的细胞作用的兴趣。肌醇缩合受体的发现和肌醇缩合作用的新机制为这些信使如何与核机械偶联提供了重要的见解。在这一章中，我们讨论了IPK家族成员及其肌醇产物调节的核过程。
Recent work has uncovered roles for inositide signalling pathways downstream of phospholipase C activation and inositol 1,4,5-trisphosphate in the regulation of nuclear processes including gene expression, mRNA export and DNA metabolism. The identification of several IPKs (inositol polyphosphate kinases) has renewed interest in the cellular roles of inositol tetra-, penta-, hexa- and pyro-phosphates. Discoveries of inositide receptors and novel mechanisms of inositide action have provided important insights into how such messengers couple to nuclear machinery. In this chapter, we discuss the IPK family members and the nuclear processes that their inositide products regulate.