REJECTION OF MURINE CARDIAC ALLOGRAFTS .1. RELATIVE ROLES OF MAJOR AND MINOR ANTIGENS
REJECTION OF MURINE CARDIAC ALLOGRAFTS .1. RELATIVE ROLES OF MAJOR AND MINOR ANTIGENS
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DOI：
10.1097/00007890-198607000-00015
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发表时间：
1986-07-01
期刊：
影响因子：
6.2
通讯作者：
CLOW, LW
中科院分区：
文献类型：
--
作者：
BURDICK, JF;CLOW, LW
I类、II类或次要抗原对主要血管化移植物注射的不相容性的相对贡献以前没有在大量菌株中进行过比较。在我们的实验中，小鼠主要血管化异位心脏移植排斥反应进行了研究，在16个供体-受体菌株组合，代表不同的精确定义的主要和/或次要的组织不相容性。完全的主要不相容性通常产生强烈的移植物排斥反应，尽管已经证实，在某些与I类抗原或I类加II类抗原不相容的组合中，存活期延长。此外，当供体仅对次要抗原不相容时，这些移植物在某些受体株中产生强烈排斥。次要抗原的这种强烈作用可能反映了其对迟发型超敏反应的强烈刺激，而II类抗原的影响似乎与刺激混合淋巴细胞培养产生淋巴细胞介导的细胞毒性更相关。
The relative contributions of incompatabilities for class I, class II, or minor antigens to primarily vascularized graft injection have not been previously compared in large numbers of strains. In our experiments, murine primarily vascularized heterotopic cardiac graft rejection was studied in 16 donor-recipient strain combinations, representing different precisely defined major and/or minor histoincompatabilities. Complete major incompatibilities generally produced strong graft rejection, although it was confirmed that prolonged survival occurs in certain combinations that are incompatible for class I, or class I plus class II, antigens. In addition, however, strong rejection of these grafts was produced in some recipient strains when the donor was incompatible only for minor antigens. This strong effect of minor antigens may reflect their strong stimulation of delayed-type hypersensitivity, whereas the influence of class II antigens seems more related to stimulation of mixed lymphocyte culture generation of lymphocyte-mediated cytotoxicity.