The mouse-human anatomy ontology mapping project
The mouse-human anatomy ontology mapping project
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DOI：
10.1093/database/bar066
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发表时间：
2012-03-20
影响因子：
5.8
通讯作者：
Ringwald, Martin
中科院分区：
文献类型：
--
作者：
Hayamizu, Terry F.;de Coronado, Sherri;Ringwald, Martin
小鼠-人类解剖学项目(MHAP)的总体目标是促进小鼠基因组信息学(MGI)和国家癌症研究所(NCI)对小鼠和人类模型使用的解剖学术语的绘制和协调。为这项研究指定的解剖学资源是成年小鼠解剖学(MA)本体和包含在NCI主题词库(NCIT)中的一组解剖学概念。确定并评估了几种方法和软件工具，然后使用它们对解剖学本体论进行了深入的比较分析。确定并验证了鼠标和人体解剖术语之间的匹配，从而产生了已被其他资源使用的两个本体之间的高度精选的映射集。这些映射将使来自鼠标和人类的数据能够链接。随着解剖本体的扩展和改进，映射也相应地进行了更新。对本体之间的比较和映射的整个过程提出了见解，这可能被证明对进一步的比较分析和本体映射工作有用，特别是那些涉及解剖本体的工作。最后，讨论了关于本体的进一步发展、映射文件的更新以及可能的其他应用和意义的问题。
The overall objective of the Mouse-Human Anatomy Project (MHAP) was to facilitate the mapping and harmonization of anatomical terms used for mouse and human models by Mouse Genome Informatics (MGI) and the National Cancer Institute (NCI). The anatomy resources designated for this study were the Adult Mouse Anatomy (MA) ontology and the set of anatomy concepts contained in the NCI Thesaurus (NCIt). Several methods and software tools were identified and evaluated, then used to conduct an in-depth comparative analysis of the anatomy ontologies. Matches between mouse and human anatomy terms were determined and validated, resulting in a highly curated set of mappings between the two ontologies that has been used by other resources. These mappings will enable linking of data from mouse and human. As the anatomy ontologies have been expanded and refined, the mappings have been updated accordingly. Insights are presented into the overall process of comparing and mapping between ontologies, which may prove useful for further comparative analyses and ontology mapping efforts, especially those involving anatomy ontologies. Finally, issues concerning further development of the ontologies, updates to the mapping files, and possible additional applications and significance were considered.