Examination of mercaptobenzyl sulfonates as catalysts for native chemical ligation: application to the assembly of a glycosylated Glucagon-Like Peptide 1 (GLP-1) analogue.
Examination of mercaptobenzyl sulfonates as catalysts for native chemical ligation: application to the assembly of a glycosylated Glucagon-Like Peptide 1 (GLP-1) analogue.
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DOI：
10.1039/c4cc09502b
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发表时间：
2015-02
影响因子：
4.9
通讯作者：
B. Cowper;Tsz Mei Sze;B. Premdjee;Aileen F Bongat White;A. Hacking;D. Macmillan
中科院分区：
文献类型：
--
作者：
B. Cowper;Tsz Mei Sze;B. Premdjee;Aileen F Bongat White;A. Hacking;D. Macmillan
研究了3/4-巯基苄基磺酸盐作为芳基硫醇催化剂用于天然化学连接（NCL）。虽然以与4-巯基苯乙酸（MPAA）相似的速率催化NCL方法，但3-巯基苄基磺酸盐的增加的极性和溶解度特别地在许多情况下可能有利于其选择作为NCL催化剂。
3/4-Mercaptobenzyl sulfonates were investigated as aryl thiol catalysts for native chemical ligation (NCL). Whilst catalysing NCL processes at a similar rate to 4-mercaptophenyl acetic acid (MPAA), the increased polarity and solubility of 3-mercaptobenzyl sulfonate in particular may favour its selection as NCL catalyst in many instances.