THE TREATMENT OF PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME BY INVITRO FERTILIZATION AND EMBRYO TRANSFER - A COMPARISON OF RESULTS WITH THOSE OF PATIENTS WITH TUBAL INFERTILITY
THE TREATMENT OF PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME BY INVITRO FERTILIZATION AND EMBRYO TRANSFER - A COMPARISON OF RESULTS WITH THOSE OF PATIENTS WITH TUBAL INFERTILITY
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DOI：
10.1093/oxfordjournals.humrep.a137189
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发表时间：
1990-10-01
影响因子：
6.1
通讯作者：
MASHIACH, S
中科院分区：
文献类型：
--
作者：
DOR, J;SHULMAN, A;MASHIACH, S
16例多囊卵巢综合征（PCO）患者接受体外受精治疗（26个治疗周期）。结果进行了比较，37例正常排卵妇女输卵管疾病（37个治疗周期）。PCO患者卵泡期雌二醇和孕酮水平较高，但仅在人绒毛膜促性腺激素给药后第二天有统计学意义。尽管PCO组每个周期回收的卵母细胞更多（19.3 ± 0.001），6.1)与对照组相比（5.4 ± 0.01），2.9)P < 0.004，两组中每个周期的平均胚胎数相似（3.7 ± 0.001）。2.4与3.6 .+-. 2.2）。两组的妊娠率也相当（分别为30.7%和29.7%）。从PCO患者中回收更多卵母细胞的事实平衡了其较低的受精率和卵裂率。因此，我们的结论是，体外受精治疗可能是一个可行的解决方案，PCO患者抵抗体内协议的治疗方案。
Sixteen patients with polycystic ovarian syndrome (PCO) were treated by in vitro fertilization (26 treatment cycles). The results were compared with 37 normo-ovulatory women with tubal disease (37 treatment cycles). The oestradiol and progesterone levels were higher during the follicular phase in the PCO patients, but were statistically significantly higher only on the day after human chorionic gonadotrophin administration. Although more oocytes were recovered per cycle from the PCO group (19.3 .+-. 6.1) than from the control group (5.4 .+-. 2.9) with P < 0.004, the mean numbers of embryos per cycle were similar in both groups (3.7 .+-. 2.4 versus 3.6 .+-. 2.2, respectively). The pregnancy rate was also comparable in both groups (30.7 versus 29.7%, respectively). The fact that more oocytes are recovered from PCO patients, balances their lower fertilization and cleavage rates. We conclude, therefore, that IVF treatment may be a viable solution for PCO patients resistant to an in vivo protocol treatment regimes.