Reduced postmovement cortical inhibition in patients with paroxysmal kinesigenic dyskinesia
Reduced postmovement cortical inhibition in patients with paroxysmal kinesigenic dyskinesia
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DOI：
10.1212/wnl.0b013e31829c5e61
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发表时间：
2013-07-23
期刊：
影响因子：
9.9
通讯作者：
Lin, Yung-Yang
中科院分区：
文献类型：
--
作者：
Hsu, Wan-Yu;Liao, Kwong-Kum;Lin, Yung-Yang
目的：为研究运动相关神经振荡活动的特征，阐明其在阵发性运动诱发性运动障碍（PKD）中的神经生理学作用，我们记录了16例PKD患者和17例健康对照者在完成一个自步速手指抬起任务时的神经磁事件相关去同步化（ERD）和事件相关同步化（ERS）活动。健康对照组和PKD患者的α-ERD振幅相当，而对侧或同侧β-ERS降低。PKD患者对侧β-ERS峰潜伏期延长。运动障碍发作频率较低的患者表现出较大的同侧β-ERS。此外，一些PKD患者显示了较小程度的对侧优势的β-ERS generation.Conclusions：目前的数据意味着减少运动后抑制PKD患者的大脑皮层，在对侧半球的抑制功能比在同侧半球的影响。
Objective: To characterize movement-related neural oscillatory activity and to clarify its neurophysiologic role in paroxysmal kinesigenic dyskinesia (PKD).Methods: We recorded neuromagnetic event-related desynchronization (ERD) and event-related synchronization (ERS) activities in response to a self-paced finger-lifting task in 16 patients with PKD and 17 healthy controls.Results: The amplitude of alpha-ERD was comparable between the healthy controls and patients with PKD, whereas either the contralateral or ipsilateral beta-ERS was decreased. The peak latency of contralateral beta-ERS was delayed in patients with PKD. Patients with less frequent dyskinetic attacks demonstrated a larger ipsilateral beta-ERS. Moreover, some patients with PKD revealed a lesser degree of contralateral preponderance of beta-ERS generation.Conclusions: The present data imply a decreased postmovement inhibition of motor cortex in patients with PKD, and the inhibitory function in the contralateral hemisphere is more affected than that in the ipsilateral hemisphere.