THE INFLUENCE OF ASCORBIC-ACID ON LIPID-PEROXIDATION IN GUINEA-PIGS INTOXICATED WITH CADMIUM
THE INFLUENCE OF ASCORBIC-ACID ON LIPID-PEROXIDATION IN GUINEA-PIGS INTOXICATED WITH CADMIUM
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DOI：
10.1016/0278-6915(92)90111-w
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发表时间：
1992-12-01
影响因子：
4.3
通讯作者：
GINTER, E
中科院分区：
文献类型：
--
作者：
HUDECOVA, A;GINTER, E
以 1 mg Cd/动物/天的剂量在饮用水中向抗坏血酸摄入量较低（2 mg/动物/天）的豚鼠施用镉（以 CdCl2 形式），治疗 5 周后会增加肾脏、肝脏和血清中的脂质过氧化 (LPO)。大量摄入抗坏血酸（100 毫克/动物/天）可降低经镉处理的豚鼠肾脏、肝脏和血清中的 LPO（根据丙二醛水平测定）。与摄入低水平抗坏血酸但不摄入镉的对照组相比，对摄入少量抗坏血酸的豚鼠施用镉后，第 5 周时肾脏中的 LPO 显着增加。然而，在第 12 周时，Cd 处理的豚鼠肾脏中的 LPO 显着低于对照组。这些结果表明，抗坏血酸摄入量低的豚鼠肾脏中脂质过氧化物的水平取决于累积的镉量。
Cadmium (as CdCl2) administered at a dose of 1 mg Cd/animal/day in drinking water to guinea pigs with a low intake of ascorbic acid (2 mg/animal/day) increased lipid peroxidation (LPO) in the kidney, liver and serum after 5 wk of treatment. A high intake of ascorbic acid (100 mg/animal/day) decreased LPO (determined from malondialdehyde levels) in the kidney, liver and serum of Cd-treated guinea pigs. Administration of Cd to guinea pigs with a low intake of ascorbic acid significantly increased LPO in the kidney at 5 wk, in comparison with controls given low levels of ascorbic acid but no Cd. However, at 12 wk, LPO in the kidney of Cd-treated guinea pigs was significantly lower than in the controls. These results indicate that the level of lipid peroxides in the kidney of guinea pigs with a low intake of ascorbic acid depends on the amount of accumulated cadmium.