Evaluation of a Delay-Line Detector Combined with Analog-to-Digital Converters as the Ion Detection System for Stigmatic Imaging Mass Spectrometry
Evaluation of a Delay-Line Detector Combined with Analog-to-Digital Converters as the Ion Detection System for Stigmatic Imaging Mass Spectrometry
复制标题
延迟线检测器与模数转换器相结合作为斑象成像质谱离子检测系统的评估
DOI：
10.1143/jjap.50.056701
复制
发表时间：
2011
影响因子：
1.5
通讯作者：
K. Awazu
中科院分区：
文献类型：
--
作者：
Hidetoshi Yoshimura;H. Hazama;J. Aoki;M. Toyoda;Yasuhide Naito;K. Awazu
除了从离子的飞行时间识别分析物之外，消像散成像质谱（IMS）还实现了多个质量分辨分子的微观和高通量成像。然而，实际应用需要快速的位置和时间敏感的离子检测器。我们开发了一种与模数转换器（ADC）相结合的延迟线检测器，并评估了其作为使用电子电离的污名IMS离子检测器的性能。该系统的空间和时间分辨率分别为230 µm和24 ns（每秒4.2 ×107帧）。我们推测，由于信号处理设备，信号的定时抖动限制了空间分辨率。在20倍离子光学放大率和m/z为10，000的情况下，使用我们目前正在开发的具有像散成像质谱仪的离子检测系统，估计空间分辨率和质量分辨率m/Δm分别为12 µm和15，000。
In addition to identifying analytes from the time-of-flight of ions, stigmatic imaging mass spectrometry (IMS) realizes microscopic and high-throughput imaging of multiple mass-resolved molecules. However, practical applications require a fast position- and time-sensitive ion detector. We have developed a delay-line detector combined with analog-to-digital converters (ADCs), and evaluated its performance as an ion detector for stigmatic IMS using electron ionization. The system shows spatial and temporal resolutions of 230 µm and 24 ns (4.2 ×107 frames per second), respectively. We speculate that the timing jitter of the signals limits the spatial resolution due to the signal processing devices. At a 20-fold ion optical magnification and m/z of 10,000, the estimated spatial resolution and mass resolving power m/Δm using this ion detection system with a stigmatic imaging mass spectrometer, which we are currently developing, are 12 µm and 15,000, respectively.
CO2 的电子电离
影响因子：
1.8
作者：
King S
通讯作者：
King S
影响因子：
11.2
作者：
N. Masumori;T. Thomas;P. Chaurand;T. Case;M. Paul;S. Kasper;R. Caprioli;T. Tsukamoto;S. Shappell;R. Matusik
通讯作者：
N. Masumori;T. Thomas;P. Chaurand;T. Case;M. Paul;S. Kasper;R. Caprioli;T. Tsukamoto;S. Shappell;R. Matusik
影响因子：
2.3
作者：
Reyzer, ML;Hsieh, YS;Caprioli, RM
通讯作者：
Caprioli, RM