Association of Adiponectin, Resistin, and Vascular Inflammation Analysis With 18F-Fluorodeoxyglucose Positron Emission Tomography
Association of Adiponectin, Resistin, and Vascular Inflammation Analysis With 18F-Fluorodeoxyglucose Positron Emission Tomography
复制标题
DOI：
10.1161/atvbaha.110.220673
复制
发表时间：
2011-04-01
影响因子：
8.7
通讯作者：
Choi, Kyung Mook
中科院分区：
文献类型：
--
作者：
Choi, Hae Yoon;Kim, Sungeun;Choi, Kyung Mook
β-脂联素和β-脂联素是与肥胖、炎症和动脉粥样硬化有关的脂肪因子。F-18-氟脱氧葡萄糖（FDG）正电子发射断层扫描是一种很有前途的成像技术，可用于评估血管inflammation.Methods和Results-We测量脂联素和lipoprotein水平，以及传统的心血管危险因素，在60名肥胖受试者和60名非肥胖对照。此外，我们比较了颈动脉内膜中层厚度和目标-背景比（TBR）测量使用F-18-氟脱氧葡萄糖-正电子发射断层扫描/计算机断层扫描。肥胖组的平均TBR值显著高于正常组，尽管他们的平均颈动脉内膜中层厚度水平没有显著差异。血清脂联素水平与TBR均值呈显著负相关（r =-0.215，P =0.020），而脂联素水平与TBR均值呈正相关（r=0.214，P=0.021）。多元线性回归分析显示，平均TBR值与体重指数、高敏C反应蛋白和脂联素水平独立相关（R-2=0.308）。结论脂联素和脂联素可作为反映血管炎症的生物标志物。特别是，即使在调整了其他心血管危险因素后，BMPN水平也与血管炎症独立相关。（Arterioscler Thromb Vasc Biol.2011;31：944-949.）
Objective-Adiponectin and resistin are adipokines that are linked to obesity, inflammation, and atherosclerosis. F-18-Fluorodeoxyglucose (FDG) positron emission tomography is a promising imaging technique that can be used to evaluate vascular inflammation.Methods and Results-We measured adiponectin and resistin levels, as well as traditional cardiovascular risk factors, in 60 obese subjects and 60 nonobese controls. In addition, we compared carotid intima-media thickness and target-to-background ratio (TBR) measured using F-18-fluorodeoxyglucose-positron emission tomography/computed tomography. The mean TBR values were significantly higher in the obese group compared with normal subjects, although their mean carotid intima-media thickness levels were not significantly different. Serum adiponectin levels showed a significant negative correlation with mean TBR values (r = -0.215, P=0.020), whereas resistin levels were positively correlated with mean TBR values (r=0.214, P=0.021). Multiple linear regression analysis showed that mean TBR values were independently associated with body mass index, high-sensitivity C-reactive protein, and resistin levels (R-2=0.308).Conclusion-Adiponectin and resistin may be useful as biomarkers to reflect vascular inflammation. In particular, resistin levels were independently associated with vascular inflammation even after adjusting for other cardiovascular risk factors. (Arterioscler Thromb Vasc Biol. 2011;31:944-949.)