Fatigue, weight gain, lethargy and amenorrhea in breast cancer patients on chemotherapy: is subclinical hypothyroidism the culprit?
Fatigue, weight gain, lethargy and amenorrhea in breast cancer patients on chemotherapy: is subclinical hypothyroidism the culprit?
复制标题
DOI：
10.1023/b:brea.0000010708.99455.e1
复制
发表时间：
2004-01-01
影响因子：
3.8
通讯作者：
Jacobsen, PB
中科院分区：
文献类型：
--
作者：
Kumar, N;Allen, KA;Jacobsen, PB
背景本研究的目的是前瞻性地观察每一个可行的机制，如暴食，体力活动，身体成分，类固醇激素和甲状腺功能，疲劳评分对乳腺癌患者的体重变化的相对贡献，接受辅助化疗。这是一项前瞻性观察性研究设计，其中198例连续接受辅助化疗的乳腺癌患者从开始到结束以及治疗后6个月监测人体测量学、疲劳、营养摄入、体力活动、甲状腺和类固醇激素的变化。我们观察到22.2%的患者体重增加>5磅，其中6.7磅的显著和渐进性增加（P
Background. The purpose of this study was to prospectively observe the relative contribution of each viable mechanism such as hyperphagia, physical activity, body composition, steroid hormonal and thyroid function, fatigue scores on changes in body weight in breast cancer patients, receiving adjuvant chemotherapy.Methods. This was a prospective observational research design where 198 consecutive breast cancer patients receiving adjuvant chemotherapy were monitored from start to end and 6 months post-therapy on changes in anthropometics, fatigue, nutritional intake, physical activity, thyroid and steroid hormones.Results. We observed a weight gain over >5 lb in 22.2% of this patient population with a significant and progressive gain of 6.7 lb (P