Cortex periplocae modulates the gut microbiota to restrict colitis and colitis-associated colorectal cancer via suppression of pathogenic Th17 cells
Cortex periplocae modulates the gut microbiota to restrict colitis and colitis-associated colorectal cancer via suppression of pathogenic Th17 cells
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Cortex periplocae 通过抑制致病性 Th17 细胞来调节肠道微生物群，从而限制结肠炎和结肠炎相关的结直肠癌
DOI：
10.1016/j.biopha.2022.113399
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发表时间：
2022-07-11
影响因子：
7.5
通讯作者：
He, Shijun
中科院分区：
文献类型：
--
作者：
Lin, Zemin;Chen, Li;He, Shijun
异常的微生物-免疫细胞相互作用是炎症性肠病（IBD）和结肠炎相关癌症（CAC）的诱发因素。香加皮是一种著名的中药，具有抗风湿性关节炎、抗消化不良等功效。在这里，我们发现 Periploca sepium periplosides (PePs) 是一种从 Cortex Periplocae 根皮中提取的不含强心苷的孕烷糖苷，可以减轻结肠炎症，改善肠上皮屏障功能，并预防结肠炎和 CAC 小鼠的结肠炎相关肿瘤发生。从机制上讲，PePs 治疗可调节模型小鼠的异常肠道微生物群组成，尤其是丰富抗炎共生菌 A. muciniphila BAA-835。我们进一步证明，PePs 治疗后肠道微生物群的改变在结肠炎和 CAC 小鼠模型中肠道 17 型免疫调节中发挥着重要作用。我们的结果表明，PeP 可作为潜在的肠道微生物调节剂来治疗 IBD 和 CAC。
Aberrant microbe-immune cell interaction is a predisposing factor in inflammatory bowel disease (IBD) and colitis-associated cancer (CAC). Cortex Periplocae is a famous traditional Chinese medicine with putative anti -rheumatoid arthritis and anti-dyspepsia effects. Here, we show that the Periploca sepium periplosides (PePs), a cardiac glycosides-free pregnane glycosides extract from root bark of Cortex Periplocae, alleviates colon inflammation, improves intestinal epithelial barrier function, and prevents colitis-associated tumorigenesis in mice with colitis and CAC. Mechanistically, PePs treatment modulates abnormal gut microbiota composition in model mice, especially enriches an anti-inflammatory commensal bacterium A. muciniphila BAA-835. We further demonstrate that the altered gut microbiota following PePs treatment plays an important role in modulation of intestinal Type 17 immunity in both colitis and CAC mouse model. Our results indicate that PePs may be used as a potential gut microbiota modulator to treat IBD and CAC.