Selenoprotein synthesis and side-effects of statins
Selenoprotein synthesis and side-effects of statins
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DOI：
10.1016/s0140-6736(04)15739-5
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发表时间：
2004-03-13
期刊：
影响因子：
168.9
通讯作者：
Behl, C
中科院分区：
文献类型：
--
作者：
Moosmann, B;Behl, C
他汀类药物可能是预防和治疗高胆固醇血症和冠心病最有效的药物。它们通常耐受性良好，然而，它们确实引起一些不寻常的副作用，具有潜在的严重后果，最突出的是肌病或横纹肌溶解和多发性神经病。我们注意到，他汀类药物相关的副作用模式类似于硒缺乏的病理学，并假设其机制在于一个完善的，但经常被忽视的生化途径-硒代半胱氨酸-tRNA（[Ser]Sec）的异戊烯化。他汀类药物对硒蛋白合成的负面影响似乎可以解释他汀类药物的许多神秘作用和副作用，特别是他汀类药物诱导的肌病。
Statins are possibly the most effective drugs for the prevention and treatment of hypercholesterolaemia and coronary heart disease. They are generally well tolerated, however, they do cause some unusual side-effects with potentially severe consequences, most prominently myopathy or rhabdomyolysis and polyneuropathy. We noted that the pattern of side-effects associated with statins resembles the pathology of selenium deficiency, and postulated that the mechanism lay in a well established, but often overlooked, biochemical pathway-the isopentenylation of selenocysteine-tRNA([Ser]Sec). A negative effect of statins on selenoprotein synthesis does seem to explain many of the enigmatic effects and side-effects of statins, in particular, statin-induced myopathy.