Transcription factor EB agonists from natural products for treating human diseases with impaired autophagy-lysosome pathway.
Transcription factor EB agonists from natural products for treating human diseases with impaired autophagy-lysosome pathway.
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来自天然产物的转录因子 EB 激动剂用于治疗自噬-溶酶体途径受损的人类疾病
DOI：
10.1186/s13020-020-00402-1
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发表时间：
2020-11-23
期刊：
影响因子：
4.9
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Xu J;Zhang XQ;Zhang Z
Autophagy is a highly conserved degradation process for long-lived intracellular proteins and organelles mediated by lysosomes. Deficits in the autophagy-lysosome pathway (ALP) have been linked to a variety of human diseases, including neurodegenerative diseases, lysosomal storage disorders, and cancers. Transcription factor EB (TFEB) has been identified as a major regulator of autophagy and lysosomal biogenesis. Increasing evidence has demonstrated that TFEB activation can promote the clearance of toxic protein aggregates and regulate cellular metabolism. Traditional Chinese medicine (TCM)-derived natural products as important sources for drug discovery have been widely used for the treatment of various diseases associated with ALP dysfunction. Herein, we review (1) the regulation of TFEB and ALP; (2) TFEB and ALP dysregulation in human diseases; (3) TFEB activators from natural products and their potential uses.
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影响因子：
16.6
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通讯作者：
Deretic V
影响因子：
4.8
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影响因子：
5.5
作者：
Huang, Jun;Wang, Xue;Lin, Fang
通讯作者：
Lin, Fang
影响因子：
4.9
作者：
Guo YP;Lin LG;Wang YT
通讯作者：
Wang YT